河南中医2025，Vol.45Issue(5)：744-748,5.DOI:10.16367/j.issn.1003-5028.2025.05.0121
筋骨消痛丸外敷联合膝关节脉冲射频治疗肝肾亏虚型膝骨关节炎50例
Fifty Cases of Liver and Kidney Deficiency Type Knee Osteoarthritis Treated with Jingu Xiaotong Pills Combined with Knee Joint Pulsed Radiofrequency
摘要
Abstract
Objective:To observe the clinical efficacy of Jingu Xiaotong Pills combined with knee joint pulsed radiofrequency on knee os-teoarthritis with syndrome of deficiency of liver and kidney.Methods:A total of 100 patients with liver-kidney deficiency type knee oste-oarthritis admitted to Henan Provincial Hospital of TCM from May 2021 to May 2022 were selected and randomly divided into the con-trol group and the treatment group,with 50 cases in each group.The treatment group was given Jinggu Xiaotong Pills combined with knee joint pulsed radiofrequency treatment,while the control group was given knee joint pulsed radiofrequency treatment alone.The clin-ical efficacy of the two groups was observed.The levels of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-7 recep-tor(IL-7R),interleukin-1β(IL-1β),nuclear transcription factor-KB receptor activating factor ligand(RANKL),cartilage oligomer matrix protein(COMP),osteoprotegerin(OPG),and type Ⅱ collagen carboxyl end-terminal peptide(CTX-Ⅱ)were detected before and after treatment in both groups.The changes in knee flexion-extension range of motion,numerical rating scale(NRS)score for pain,knee motor function Lysholm scale(LKSS),Western Ontario and McMaster University Osteoarthritis Index(WOMAC),and clinical symptom scores before and after treatment were compared between the two groups.Results:The effective rate of the treatment group was 96.0％,which was higher than that of the control group(80.0％)(P＜0.05).After treatment,the levels of IL-1,TNF-α,and IL-1βin both groups were lower than those before treatment,while the level of IL-7R was higher than that before treatment,and there were sta-tistically significant differences between the two groups(P＜0.05);the levels of RANKL,COMP,and CTX-Ⅱ in both groups were low-er than those before treatment(P＜0.05),while the level of OPG was higher than that before treatment,and there were statistically sig-nificant differences between the two groups(P＜0.05);the NRS scores of both groups were lower than those before treatment,while the joint range of motion was higher than that before treatment,and there were statistically significant differences between the two groups(P＜0.05);the WOMAC and clinical symptom scores of both groups were lower than those before treatment,while the LKSS scores were higher than those before treatment,and there were statistically significant differences between the two groups(P＜0.05).Conclu-sion:For patients with knee osteoarthritis of liver-kidney deficiency type,Jingu Xiaotong Pills combined with knee joint pulsed radiofre-quency can inhibit inflammation,regulate bone metabolism,reduce cartilage and synovial membrane damage,relieve pain,improve joint range of motion and joint function,and has a definite therapeutic effect.关键词
膝骨关节炎/肝肾亏虚证/筋骨消痛丸/膝关节脉冲射频/外敷疗法Key words
knee osteoarthritis/syndrome of deficiency of liver and kidney/Jingu Xiaotong Pills/knee joint pulsed radiofrequency/exter-nal application therapy分类
医药卫生引用本文复制引用
张慧芳,王勤俭..筋骨消痛丸外敷联合膝关节脉冲射频治疗肝肾亏虚型膝骨关节炎50例[J].河南中医,2025,45(5):744-748,5.基金项目
河南省中医药科学研究专项课题项目(20-21ZY2120) （20-21ZY2120）
