实用临床医药杂志2025，Vol.29Issue(8)：35-39,5.DOI:10.7619/jcmp.20245474
基于电阻抗断层成像技术评估急性大面积脑梗死患者不同降颅压方案的疗效
Efficacy of different intracranial pressure-lowering regimens in patients with acute large-area cerebral infarction based on electrical impedance tomography
摘要
Abstract
Objective To evaluate the therapeutic effects of different intracranial pressure lower-ing regimens in patients with acute large-area cerebral infarction based on electrical impedance tomo-graphy(EIT)technology.Methods A total of 75 patients with acute large-area cerebral infarction were selected as the study subjects and randomly divided into study group(n=40,using mannitol combined with albumin to decrease intracranial pressure)and control group(n=35,using mannitol alone to decrease intracranial pressure).EIT technology was used to continuously monitor the changes in intracranial pressure within 48 hours in the patients.Clinical data of the two groups were collected,and the 24-hour intracranial pressure change rate,48-hour intracranial pressure change rate,ICU stay duration,hospitalization duration,antibiotic use duration,and National Institutes of Health Stroke Scale(NIHSS)score at discharge were observed and compared between the two groups.A 90-day sur-vival follow-up was also conducted.Results There was no statistically significant difference in the 24-hour intracranial pressure change rate between the two groups(P＞0.05).The 48-hour intracrani-al pressure change rate in the study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The ICU stay duration,hospitalization duration,and antibiotic use duration in the study group were all shorter than those in the control group,and the NIHSS score at discharge in the study group was lower than that in the control group,with statistically significant differences(P＜0.05).The follow-up results showed that the survival duration in the study group was longer than that in the control group,and the 90-day cumulative survival rate in the study group was higher than that in the control group,but the differences were not statistically significant(P＞0.05).The modified Rankin Scale score in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Compared with the use of mannitol alone,early use of mannitol combined with albumin can effectively decrease the in-tracranial pressure within 48 hours,shorten the hospitalization duration,and improve neurological function in patients with acute large-area cerebral infarction.关键词
急性大面积脑梗死/电阻抗断层成像/颅内压/白蛋白/甘露醇/神经功能/住院时间/预后Key words
acute large-area cerebral infarction/electrical impedance tomography/intracra-nial pressure/albumin/mannitol/neurological function/hospitalization duration/prognosis分类
医药卫生引用本文复制引用
陶路航,杭景,陈昕,刘晓光,董理,胡爱鹏,李育平,于海龙..基于电阻抗断层成像技术评估急性大面积脑梗死患者不同降颅压方案的疗效[J].实用临床医药杂志,2025,29(8):35-39,5.基金项目
江苏省基础研究计划自然科学基金项目(BK20221280) （BK20221280）
2022年江苏省扬州市级计划——社会发展项目(YZ2022097) （YZ2022097）
江苏省卒中学会菁英人才培育项目(N-2023-15-23) （N-2023-15-23）
