军事医学2025，Vol.49Issue(3)：198-206,9.DOI:10.7644/j.issn.1674-9960.2025.03.006
幽门螺杆菌感染与骨质疏松症相关性荟萃分析
Correlations between Helicobacter pylori infection and osteoporosis:a Meta-analysis
摘要
Abstract
Objective To study the relationships between Helicobacter pylori(Hp)infection and the occurrence of osteoporosis via Meta-analysis.Methods Two researchers independently retrieved related literature related to the association between Hp infection and osteoporosis and published in such databases as PubMed,EMBASE and Cochrane Library,China Science and Technology Journal Database,China National Knowledge Infrastructure(CNKI),and Wanfang Database as of February 2024.STATA 11.0 software was used for Meta-analysis before the combined OR value and its 95％CI were calculated.Results Twenty-four studies involving 24 936 participants were included in the study.Meta-analysis showed that Hp infection was significantly associated with the risk of osteoporosis(OR:1.52,95％CI:1.17-1.99).Those infected with the CagA-positive Hp strain were more likely to develop osteoporosis(OR:2.42,95％CI:1.32-4.43).Hp infection was significantly associated with decreased bone mass(OR=1.32,95％CI:1.08-1.62),but the decrease of bone mineral density in Hp-positive patients was not significant compared with Hp negative controls.Conclusion Infection with Hp,particularly the CagA-positive strain,has been associated with an increased risk of osteoporosis.The bone health of Hp-positive patients deserves more attention.关键词
幽门螺杆菌/骨质疏松症/骨量减少/骨密度/荟萃分析Key words
Helicobacter pylori/osteoporosis/osteopaenia/bone mineral density/Meta-analysis分类
临床医学引用本文复制引用
岳春艳,彭一,董陆玲..幽门螺杆菌感染与骨质疏松症相关性荟萃分析[J].军事医学,2025,49(3):198-206,9.基金项目
张家口市重点研发计划资助项目(1921097D) （1921097D）
