实用临床医药杂志2025，Vol.29Issue(8)：52-57,6.DOI:10.7619/jcmp.20244400
急性脑梗死患者血清血小板活化复合物-1、可溶性肿瘤坏死因子样凋亡微弱诱导剂水平与神经功能缺损及临床预后的相关性
Correlations of serum levels of platelet activation complex-1 and soluble tumor necrosis factor-like weak inducer of apoptosis with neurological deficit and clinical prognosis in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the correlations of serum levels of platelet activation com-plex-1(PAC-1)and soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK)with neu-rological deficit and clinical prognosis in patients with acute cerebral infarction(ACI).Methods A total of 170 ACI patients(ACI group)and 85 healthy volunteers(control group)were enrolled in this study.Based on severity of neurological deficit assessed by the National Institutes of Health Stroke Scale(NIHSS)score,ACI patients were divided into of mild neurological deficit group(43 cases),moderate neurological deficit group(57 cases),moderate-to-severe neurological deficit group(37 cases),and severe neurological deficit group(33 cases).Additionally,based on the 6-month fol-low-up prognosis,ACI patients were divided into 51 cases of poor prognosis group and 119 cases of good prognosis group.Enzyme-linked immunosorbent assay was used to measure serum levels of PAC-1 and sTWEAK.Spearman correlation analysis was performed to evaluate their correlations with NIHSS scores in ACI patients.Multivariate unconditional Logistic regression analysis was conducted to determine their relationships with clinical prognosis.Receiver operating characteristic curves were used to explore their evaluation efficacy for poor clinical prognosis.Results Serum levels of PAC-1 and sTWEAK were significantly higher in the ACI group than in the control group(P＜0.05).Ser-um levels of PAC-1 and sTWEAK increased sequentially in the mild,moderate,moderate-to-severe,and severe neurological deficit groups(P＜0.05).Spearman correlation analysis showed that serum levels of PAC-1 and sTWEAK were positively correlated with NIHSS scores in ACI patients(rs=0.715 and 0.706,respectively;P＜0.001).Multivariate unconditional Logistic regression analysis revealed that older age,higher NIHSS score,larger infarct volume,higher PAC-1 level,and higher sTWEAK level were independent risk factors for poor prognosis in ACI patients(P＜0.05).The ar-ea under the curve for the combined assessment of serum PAC-1 and sTWEAK levels for poor clini-cal prognosis in ACI patients was 0.895,which was greater than the areas under the curve for the individual assessments(0.792 and 0.786,respectively;P＜0.05).Conclusion Elevated serum levels of PAC-1 and sTWEAK are closely related to increased neurological deficit and poor clinical prognosis in ACI patients.The combined detection of these two markers has high evaluation efficacy for clinical prognosis in ACI patients.关键词
急性脑梗死/血小板活化复合物-1/可溶性肿瘤坏死因子样凋亡微弱诱导剂/神经功能缺损/临床预后/梗死体积/美国国立卫生研究院卒中量表评分/年龄Key words
acute cerebral infarction/platelet activation complex-1/soluble tumor necrosis factor-like weak inducer of apoptosis/neurological deficit/clinical prognosis/infarct volume/Na-tional Institutes of Health Stroke Scale score/age分类
医药卫生引用本文复制引用
徐国栋,董晓莉,梁晓辉,马良..急性脑梗死患者血清血小板活化复合物-1、可溶性肿瘤坏死因子样凋亡微弱诱导剂水平与神经功能缺损及临床预后的相关性[J].实用临床医药杂志,2025,29(8):52-57,6.基金项目
2024年度河北省医学适用技术跟踪项目(GZ2024006) （GZ2024006）
