军事医学2025，Vol.49Issue(3)：233-238,6.DOI:10.7644/j.issn.1674-9960.2025.03.011
低氧诱导因子与机体低氧耐力的研究进展
Research progress in hypoxia inducible factors and body hypoxia tolerance
摘要
Abstract
Hypoxia inducible factors(HIFs)are core molecules that enable the body to adapt to hypoxia environments.By sensing changes in intracellular oxygen pressure,HIFs regulate gene expression related to hypoxia adaptation,thereby enhancing the body's hypoxia tolerance at cellular,tissue and organ levels.On the other hand,HIFs promote the generation of red blood cells,angiogenesis,and regulate the body's energy metabolism,thereby improving its hypoxia tolerance.The enhancement of hypoxia tolerance is of great significance for the prevention and treatment of hypoxia-related diseases,upgrading of athletes'performance,enhancement of workers'efficiency at high-altitudes,and the improvement of individu-als'quality of life.This article reviews the relationships between HIFs and hypoxia tolerance as well as related mechanisms in order to provide strategies for enhancing hypoxia tolerance in the body.关键词
低氧诱导因子/低氧耐力/低氧适应/高原Key words
hypoxia inducible factors/hypoxia tolerance/hypoxia adaption/plateau分类
生物学引用本文复制引用
仁青扎西,杨皓,王瑞,梁雅楠,柴锐青,张沛然,张同梅,赵星成..低氧诱导因子与机体低氧耐力的研究进展[J].军事医学,2025,49(3):233-238,6.基金项目
国家自然科学基金项目(82304019) （82304019）
空军军医大学i军事医学与航空医学重大问题科技攻关项目(2022ZZXM013) （2022ZZXM013）
