实用临床医药杂志2025，Vol.29Issue(8)：132-137,6.DOI:10.7619/jcmp.20251290
长链非编码RNA通过调控有氧糖酵解代谢-表观遗传协同轴驱动胶质瘤恶性发展的研究进展
A review of long non-coding RNA regulating aerobic glycolysis metabolism-epigenetic synergistic axis driving malignant progression of glioma
摘要
Abstract
Glioma is the most common primary tumor of the central nervous system,with glio-blastoma multiforme of World Health Organization grade Ⅳ exhibiting the highest malignancy and worst prognosis.Long non-coding RNA(lncRNA)is a type of regulatory RNA without protein-coding ability,which can promote the malignant phenotypic evolution of glioma cells and induce therapeutic resistance by reprogramming glycolytic metabolism,playing a crucial role in the malignant progression and prognosis of glioma.This paper mainly introduced the role of lncRNA in regulating the biological behavior of glioma cells and aerobic glycolysis,and proposed a new paradigm of combined therapy based on the aerobic glycolysis metabolism-epigenetic network,providing new ideas for the discovery of diagnostic biomarkers and the development of novel therapeutic strategies for glioma.关键词
长链非编码RNA/胶质母细胞瘤/有氧糖酵解/代谢-表观遗传互作/糖酵解代谢重编程/生物标志物/治疗抵抗/联合治疗新范式Key words
long non-coding RNA/glioblastoma/aerobic glycolysis/metabolism-epigenetic interaction/glycolytic metabolism reprogramming/biomarker/therapeutic resistance/new paradigm of combined therapy分类
医药卫生引用本文复制引用
兰馨蕊,刘子琦,王若荀,钱莉..长链非编码RNA通过调控有氧糖酵解代谢-表观遗传协同轴驱动胶质瘤恶性发展的研究进展[J].实用临床医药杂志,2025,29(8):132-137,6.基金项目
江苏省研究生科研与实践创新计划(KYCX24_3841,KYCX22_3566) （KYCX24_3841,KYCX22_3566）
