实用临床医药杂志2025，Vol.29Issue(8)：143-148,6.DOI:10.7619/jcmp.20243699
神经退行性疾病异常脂质代谢的研究进展
Aduances of abnormal lipid metabolism in neurodegenerative diseases
摘要
Abstract
Lipids play biological roles in brain growth and development,including energy stor-age,cellular signal transduction,hormone synthesis,and homeostasis maintenance.Lipid dysregula-tion is closely associated with the occurrence and progression of neurodegenerative diseases,making brain lipids important biomarkers for assessing early diagnosis and prognosis of neurological disorders.This article reviewed abnormal lipid metabolism in Alzheimer's disease,Parkinson's disease,and multiple system atrophy,focusing on the possible mechanisms of interaction between β-amyloid(A β),α-synuclein(α-syn),phosphorylated Tau protein,and associated lipids and their metabo-lites.It also summarized key targets for improving neurodegeneration through intervention in brain lip-id metabolism pathways.关键词
脂质/大脑发育/神经退行性疾病/阿尔茨海默病/帕金森病/多系统萎缩/异常脂质代谢/干预靶点Key words
lipid/brain development/neurodegenerative disease/Alzheimer's disease/Par-kinson's disease/multiple system atrophy/abnormal lipid metabolism/intervention target分类
医药卫生引用本文复制引用
卢菁,朱梦卓,朱夕陈,马涛..神经退行性疾病异常脂质代谢的研究进展[J].实用临床医药杂志,2025,29(8):143-148,6.基金项目
江苏省基础研究计划自然科学基金面上项目(BK20221201) （BK20221201）
江苏省无锡市"双百"中青年医疗卫生拔尖人才项目(BJ2020023) （BJ2020023）
