精准医学杂志2025，Vol.40Issue(2)：112-116,5.DOI:10.13362/j.jpmed.202540012
非痴呆人群脑脊液可溶性TREM-1与阿尔茨海默病生物标志物及认知功能的关系
Correlation of soluble triggering receptor expressed on myeloid cells-1 in cerebrospinal fluid with Alzheimer's disease biomarkers and cognitive function in non-dementia individuals
摘要
Abstract
Objective To investigate the correlation of soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in cerebrospinal fluid(CSF)with core Alzheimer's disease(AD)biomarkers and cognitive function in non-dementia individuals.Methods A total of 558 non-dementia individuals in the Alzheimer's Disease Neuroimaging Initiative cohort were enrolled as subjects,and related indicators were collected,including demographic features,the levels of neuroinflammatory marker sTREM-1,amyloid-β 42(Aβ42),total tau(t-tau),and phosphorylated tau(p-tau)in CSF,and cognitive function scores assessed by Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA).A multiple linear regression analysis was used to investigate the linear correlation between sTREM-1 in CSF and core AD biomarkers and cognitive function,and the mediation analysis was used to explore whether the core AD biomarkers in CSF mediated the association between sTREM-1 and cognitive function.Results The multiple linear regression analysis showed that the level of sTREM-1 in CSF was negatively cor-related with MMSE and MoCA scores(P＜0.05)and was positively correlated with p-tau,t-tau,p-tau/Aβ42 ratio,and t-tau/Aβ42 ratio in CSF(P＜0.05),while it was not significantly correlated with the level of Aβ42 in CSF(P＞0.05).The mediation analysis showed that p-tau and t-tau in CSF mediated the association between sTREM-1 and cognitive function.Conclusion In non-dementia individuals,the level of sTREM-1 in CSF is positively correlated with the levels of t-tau and p-tau in CSF.Neuroin-flammation is involved in the pathogenesis of AD and the process of cognitive decline by affecting abnormal phosphorylation and ag-gregation of tau protein in neurons.关键词
阿尔茨海默病/认知功能障碍/Tau病变/髓系细胞触发受体-1/生物标记Key words
Alzheimer disease/Cognitive dysfunction/Tauopathies/Triggering receptor expressed on myeloid cells-1/Biomarkers分类
临床医学引用本文复制引用
郭海华,王会福..非痴呆人群脑脊液可溶性TREM-1与阿尔茨海默病生物标志物及认知功能的关系[J].精准医学杂志,2025,40(2):112-116,5.基金项目
中国科技创新2023-"脑科学与类脑研究"重大项目(2022ZD0211600) （2022ZD0211600）
