精准医学杂志2025，Vol.40Issue(2)：117-120,126,5.DOI:10.13362/j.jpmed.202540015
胰腺导管腺癌组织中DLGAP5表达水平及其与患者预后的关系
Correlation between DLGAP5 expression in pancreatic ductal adenocarcinoma tissue and patient prognosis
摘要
Abstract
Objective To measure the expression of discs large-associated protein 5(DLGAP5)in pancreatic ductal ade-nocarcinoma(PDAC)tissue,and to analyze its correlation with clinicopathological features and patient prognosis.Methods A total of 75 patients with PDAC who underwent surgical resection in Qingdao Municipal Hospital from September 2018 to December 2022 were selected.Immunohistochemical(IHC)staining was used to measure the expression of DLGAP5 protein in tumor and ad-jacent normal tissues.Patients with positive DLGAP5 expression were divided into low and high DLGAP5 expression groups ac-cording to DLGAP5 expression levels.The correlation between clinicopathological features and DLGAP5 expression levels was ana-lyzed.A multivariate Cox regression model was used to analyze the prognostic risk factors in patients with positive DLGAP5 ex-pression.A Kaplan-Meier survival curve was plotted to analyze the relationship between DLGAP5 expression levels and survival rates in these patients.Results IHC staining showed significantly higher expression DLGAP5 levels in PDAC tumor tissues than in adjacent normal tissues(x2=36.930,P＜0.05).Clinical data analysis showed significant differences between the low and high DLGAP5 expression groups in tumor differentiation,T stage,lymph node metastasis,and American Joint Committee on Cancer stage(x2=6.222-10.940,P＜0.05).Multivariate Cox regression model analysis showed that high DLGAP5 expression was an independent risk factor for poor prognosis in patients with positive DLGAP5 expression.The Kaplan-Meier survival curve showed that the cumulative survival rate was significantly lower in patients with high DLGAP5 expression than in those with low expression(x2=18.929,P＜0.05).Conclusion DLGAP5 is highly expressed in the tumor tissues of patients with poorly diffe-rentiated PDAC,stage T3+T4 tumor,lymph node metastasis,and stage Ⅱ+Ⅲ tumor.High DLGAP5 expression correlates with the poor prognosis in patients with PDAC.DLGAP5 shows promise as a new biomarker for PDAC diagnosis and prognosis.关键词
癌,胰腺管/腺癌/Discs大同源物关联蛋白5/危险因素/预后Key words
Carcinoma,pancreatic ductal/Adenocarcinoma/Discs large-associated protein 5/Risk factors/Prognosis分类
临床医学引用本文复制引用
张文姣,谢方瑜,张巍巍,付来琳,吕梅,刘静依,郝明星,解祥军..胰腺导管腺癌组织中DLGAP5表达水平及其与患者预后的关系[J].精准医学杂志,2025,40(2):117-120,126,5.基金项目
青岛市民生科技计划项目(19-6-1-22-nsh) （19-6-1-22-nsh）
