精准医学杂志2025，Vol.40Issue(2)：121-126,6.DOI:10.13362/j.jpmed.202540043
主观认知下降患者的轻微抑郁和焦虑症状特征分析
An analysis of minimal depressive symptoms and minimal anxiety symptoms in patients with subjec-tive cognitive decline
摘要
Abstract
Objective To investigate the characteristics of minimal depressive symptoms(MDS)and minimal anxiety symptoms(MAS)in patients with subjective cognitive decline(SCD),and to provide a basis for early prevention and treatment of Alzheimer's disease.Methods From the Chinese Alzheimer's Biomarker and LifestylE(CABLE)study cohort,a total of 1 982 participants were included.Based on the criteria established by the international SCD initiative workgroup,the participants were di-vided into non-SCD group and SCD group(further divided into SCD-nonplus group and SCD-plus group by the severity of SCD as-sessed using a Likert scale).All the participants were evaluated for MDS and MAS status using the Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA).Multiple linear regression and logistic regression models were employed to ana-lyze the relationships between SCD status and HAMD and HAMA scores as well as MDS and MAS status.One-way analysis of va-riance was performed to compare HAMD and HAMA scores between the non-SCD group,SCD-nonplus group,and SCD-plus group.A mediation model was utilized to analyze the mediating effects of HAMD and HAMA scores on the relationship between SCD severity and Chinese Modified Mini-Mental State Examination(CM-MMSE)score.Results The multiple linear regression analysis showed that SCD status was positively associated with HAMD and HAMA scores(β=0.045,0.057,t=4.528,5.832,P＜0.05).The logistic regression analysis revealed that SCD status was positively associated with MDS and MAS status(β=0.579,0.741,Z=4.242,5.329,P＜0.05).The HAMD and HAMA scores in the SCD-plus group were significantly higher than those in the non-SCD group and the SCD-nonplus group(t=-7.058--2.321,P＜0.05).The mediation analysis indicated that HAMD score partially mediated the relationship between SCD severity and CM-MMSE score.Conclusion Patients with SCD,particu-larly those with SCD-plus,present with more severe MDS and MAS,suggesting that MDS and MAS may have potential value in the early identification and prevention of Alzheimer's disease.关键词
认知功能障碍/抑郁/焦虑/精神病状态评定量表/阿尔茨海默病Key words
Cognitive dysfunction/Depression/Anxiety/Psychiatric status rating scales/Alzheimer disease分类
临床医学引用本文复制引用
崔瑞萍,高佩阳,陈彦明,王煜东,谭梦姗,谭兰..主观认知下降患者的轻微抑郁和焦虑症状特征分析[J].精准医学杂志,2025,40(2):121-126,6.基金项目
国家自然科学基金面上项目(8227052436) （8227052436）
