昆明医科大学学报2025，Vol.46Issue(4)：1-7,7.DOI:10.12259/j.issn.2095-610X.S20250401
青蒿素及其衍生物在癌症治疗中作用机制的研究进展
Research Progress on the Mechanisms of Action of Artemisinin and Its Derivatives in Cancer Therapy
摘要
Abstract
Due to their unique peroxide bridge structure,artemisinin and its derivatives have demonstrated the remarkable efficacy in treating severe malaria and exhibited the potent anticancer properties.These compounds interfere with the cancer cell growth through the multiple mechanisms,including the inhibition of cell proliferation,induction of various forms of cell death,cell cycle arrest,suppression of angiogenesis and modulation of the tumor microenvironment.Clinical trials have confirmed the significant anticancer activity of artemisinin-based compounds.This paper summarizes the recent advances and findings regarding the mechanisms of action of artemisinin and its derivatives as the potential anticancer agents,providing the valuable insights for future researches on the anticancer mechanisms of these compounds.关键词
青蒿素/青蒿素衍生物/抗肿瘤/作用机制Key words
Artemisinin/Artemisinin derivatives/Anticancer/Mechanisms of action分类
临床医学引用本文复制引用
曾维兴,何永文..青蒿素及其衍生物在癌症治疗中作用机制的研究进展[J].昆明医科大学学报,2025,46(4):1-7,7.基金项目
国家自然科学基金(82460520) （82460520）
