吴静 1任韶康 1郑乾佑 1朱秋阳 1李慎玲 1张晓雯 1付涛1
作者信息
- 1. 青岛大学附属医院耳鼻咽喉头颈外科,山东青岛 266035
- 折叠
摘要
Abstract
Objective To investigate the effect of preoperative blood lipid levels on the therapeutic efficacy of sigmoid si-nus bone wall reconstruction in patients with pulsatile tinnitus caused by sigmoid sinus disease.Methods A total of 43 patients with pulsatile tinnitus caused by sigmoid sinus disease who underwent sigmoid sinus bone wall reconstruction in Department of Oto-rhinolaryngology Head and Neck Surgery in our hospital from May 2019 to September 2022 were enrolled in this study,and accor-ding to the degree of improvement in tinnitus after surgery,they were divided into cured group,response group,and non-response group.Related data were collected and compared between groups,including general information,the serum levels of low-density lipoprotein(LDL),high-density lipoprotein,apolipoprotein A1(APOA1),apolipoprotein B(APOB),free fatty acid(FFA),tri-glyceride,and total cholesterol(TC),and APOB/APOA1 ratio before surgery.Results Among the 43 patients,24 were cured,14 showed response,and 5 showed no response.The serum levels of LDL,APOB,FFA,and TC and APOB/APOA1 ratio were significantly higher than the normal reference values,while the level of APOA1 was significantly lower than the normal refe-rence value(t=3.683-9.713,P＜0.05),and the non-response group had a significantly higher APOB/APOA1 ratio than the ot-her two groups(F=7.527,q=3.120,3.650,P＜0.05).Conclusion Sigmoid sinus bone wall reconstruction can effectively alle-viate the symptoms of patients with pulsatile tinnitus caused by sigmoid sinus disease,and abnormal blood lipid levels before sur-gery may compromise the efficacy of surgery by interfering with bone reconstruction.Preoperative evaluation of blood lipid levels,especially APOB/APOA1 ratio,can help to predict surgical outcome,thereby providing efficient treatment for patients.关键词
耳鸣/血脂异常/颅窦/憩室/骨重建/治疗结果Key words
Tinnitus/Dyslipidemias/Cranial sinuses/Diverticulum/Bone remodeling/Treatment outcome分类
医药卫生
