昆明医科大学学报2025，Vol.46Issue(4)：67-76,10.DOI:10.12259/j.issn.2095-610X.S20250409
康复新液联合单磷酸阿糖腺苷治疗小儿疱疹性口腔炎安全性和有效性的Meta分析
Meta-analysis of the Efficacy and Safety of Kangfuxin Combined with Adenosine Monophosphate in the Treatment of Paediatric Herpetic Stomatitis
摘要
Abstract
Objective To systematically evaluate the safety and efficacy of Kangfuxin liquid combined with adenosine monophosphate in the treatment of paediatric herpetic stomatitis.Methods Randomised controlled trials(RCTs)of Kangfuxin liquid combined with adenosine monophosphate for the treatment of paediatric herpetic stomatitis were searched in various databases,and Meta-analysis was performed using RevMan 5.4 software.Results A total of 12 RCTs with a sample size of 1,094 cases were included.Meta-analysis showed that the combination of Kangfuxin liquid with adenosine monophosphate significantly increased[RR=1.21,95%CI(1.16,1.28),P<0.000 01]the overall clinical efficacy rate of paediatric herpetic stomatitis.Compared with the conventional antiviral treatment group with adenosine monophosphate,the incidence of adverse events was lower in the Kangfuxin liquid group[RR=0.26,95%CI(0.14,0.51),P<0.000 01].In addition,the Kangfuxin liquid group could effectively shorten the time for herpes disappearance(skin lesion healing),pain disappearance,fever reduction,salivation disappearance and recovery of diet(P<0.05),and had advantages in promoting the recovery of lymphocytes(CD3+,CD4+,CD8+,and CD4+/CD8+),serological levels(CRP,TNF-α,WBC,IL-10,VEGF,EGF,and IL-6)(P<0.05).Conclusion Kangfuxin liquid combined with adenosine monophosphate has the better efficacy and safety in the treatment of paediatric herpetic stomatitis,and has advantages in shortening the symptomatic recovery time and improving the indicators of lymphocyte and serological levels in paediatric herpetic stomatitis.关键词
康复新液/单磷酸阿糖腺苷/疱疹性口腔炎/Meta分析Key words
Kangfuxin/Adenosine monophosphate/Herpes stomatitis/Meta-analysis分类
临床医学引用本文复制引用
樊浩,吴雪娇,程振宇,唐修柏,刘幸,黄会..康复新液联合单磷酸阿糖腺苷治疗小儿疱疹性口腔炎安全性和有效性的Meta分析[J].昆明医科大学学报,2025,46(4):67-76,10.基金项目
云南省教育厅科学研究基金(2024J0879) （2024J0879）
昆明市卫生科研基金(2021-03-08-006) （2021-03-08-006）
昆明市卫生科技人才培养十百千工程基金(2021-SW-13) （2021-SW-13）
