检验医学与临床2025，Vol.22Issue(9)：1184-1188,1193,6.DOI:10.3969/j.issn.1672-9455.2025.09.006
三阴性乳腺癌组织中MMP-2、CXCR4、CARNS1的表达及与淋巴结转移的关系
Expression of MMP-2,CXCR4 and CARNS1 in triple negative breast cancer tissues and their relationship with lymph node metastasis
摘要
Abstract
Objective To investigate the expression of matrix metalloproteinase-2(MMP-2),chemokine receptor 4(CXCR4)and carnosine synthase 1(CARNS1)in triple negative breast cancer(TNBC)tissues and their relationship with lymph node metastasis.Methods Tissue samples of TNBC and paracancerous tissue samples(2 cm away from the lesion)were collected from 90 female TNBC patients who underwent surgery in this hospital from April 2022 to March 2024.The expression of MMP-2,CXCR4 and CARNS1 in 90 cases of TNBC tissues and paracancerous tissues were detected by immunohistochemistry.The relationship between the expression of MMP-2,CXCR4 and CARNS1 in TNBC tissues with lymph node metastasis was investiga-ted.The clinical data of the patients were collected.The multivariate Logistic regression was used to analyze the factors affecting lymph node metastasis in TNBC.Results Compared with paracancerous tissues,the posi-tive expression rates of MMP-2 and CXCR4 in TNBC tissues were significantly increased(P＜0.05),while the positive expression rate of CARNS1 was significantly decreased(P＜0.05).Compared with TNBC pa-tients without lymph node metastasis,the positive expression rates of MMP-2 and CXCR4 in cancer tissues and the proportion of cancer thrombus in the vascular vessels in the TNBC patients with lymph node metasta-sis all were increased(P＜0.05),while the positive expression rate of CARNS1 was decreased(P＜0.05).There were no statistically significant differences in the positive expression rates of MMP-2,CXCR4,and CARNS1 in cancer tissues among TNBC patients with different ages,maximum tumor diameters,TNM sta-ges,numbers of primary lesions,and histological grades(P＞0.05).Compared with TNBC patients without intravascular cancer thrombus,TNBC patients with intravascular cancer thrombus had higher positive expres-sion rates of MMP-2 and CXCR4 in cancer tissues(P＜0.05),while the positive expression rate of CARNS1 was decreased(P＜0.05).Conclusion The positive expression rates of MMP-2 and CXCR4 in TNBC tissues are increased,while the positive expression rate of CARNS1 is decreased.The expression of the three is related to lymph node metastasis.关键词
三阴性乳腺癌/基质金属蛋白酶-2/趋化因子受体4/肌肽合酶1/淋巴结转移Key words
triple negative breast cancer/matrix metalloproteinase-2/chemokine receptor 4/carnosine synthase 1/lymph node metastasis分类
临床医学引用本文复制引用
吴瑞,赵春兰,臧鹏,魏向阳..三阴性乳腺癌组织中MMP-2、CXCR4、CARNS1的表达及与淋巴结转移的关系[J].检验医学与临床,2025,22(9):1184-1188,1193,6.基金项目
河北省保定市科技计划项目(2341ZF300). （2341ZF300）
