昆明医科大学学报2025，Vol.46Issue(4)：99-108,10.DOI:10.12259/j.issn.2095-610X.S20250413
EGFR基因多态性与云南汉族人群非小细胞肺癌的关联性
Correlation of EGFR Gene Polymorphisms with Non-small Cell Lung Cancer in Yunnan Han Population
摘要
Abstract
Objective To investigate the correlation between the epidermal growth factor receptor(EGFR)gene polymorphisms and non-small cell lung cancer(NSCLC)in Yunnan Han population.Methods A total of 407 NSCLC patients and 526 healthy controls were included.Five SNPs(rs1050171,rs2072454,rs2227983,rs1140475 and rs2293347)in EGFR were genotyped using TaqMan assay.The association between SNPs and NSCLC,as well as pathological types,were analyzed.Results In dominant mode,rs2072454 C/T-T/T may be a risk factor for NSCLC(P=0.004;OR=1.50,95%CI 1.14～1.96).There was a significant difference in genotype frequency between the SCC group and the control group(P=0.007),but no difference in allele frequency after Bonferroni correction(P>0.01);In the dominant mode,C/T-T/T at this locus relative to C/C was a risk for AC(P=0.002;OR=1.86,95%CI 1.24～2.80).rs1050171 A/A had a significantly higher risk of SCC in recessive mode(P=0.006,OR=2.66,95%CI 1.33～5.33).In dominant mode,rs2227983 A/G-G/G/G was a risk factor for the development of SCC relative to A/A(P=0.007;OR=1.83,95%CI 1.15～2.89).Conclusion The SNPs rs2072454,rs1050171 and rs2227983 in EGFR gene may be associated with the risk of NSCLC development as well as the type of pathology in Yunnan Han population.关键词
非小细胞肺癌/EGFR基因/单核苷酸多态性/关联性Key words
Non-small cell lung cancer/EGFR/Single nucleotide polymorphism/Correlation分类
医药卫生引用本文复制引用
李盈甫,郭妮,罗正光,邢安灏,李太福,马千里..EGFR基因多态性与云南汉族人群非小细胞肺癌的关联性[J].昆明医科大学学报,2025,46(4):99-108,10.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金(202201AY070001-141) （202201AY070001-141）
保山市科技计划项目-医学研究联合专项基金(2023bskjylms016) （2023bskjylms016）
