检验医学与临床2025，Vol.22Issue(9)：1189-1193,5.DOI:10.3969/j.issn.1672-9455.2025.09.007
原发性骨质疏松症患者血清Smad7、OPG水平及其临床意义
Serum Smad7 and OPG levels in patients with primary osteoporosis and their clinical significance
摘要
Abstract
Objective To explore serum Smad homolog 7(Smad7)and osteoprotegerin(OPG)levels in the patients with primary osteoporosis(POP)and their clinical significance.Methods A total of 122 patients with POP admitted and treated in this hospital from March 2023 to February 2024 were prospectively selected as the POP group,and 131 healthy volunteers undergoing physical examinations without complicating POP in the same period were set as the control group.Serum Smad7 and OPG levels were detected by enzyme-linked immunosorbent assay(ELISA),and serum type Ⅰ procollagen amino-terminal propeptide(PⅠNP),os-teopontin(OPN),β-Crosslaps(β-CTX)and osteocalcin(OST)were detected by electrochemiluminescence immunoassay.Pearson correlation was used to analyze the correlation between serum Smad7 and OPG levels with the bone metabolism indicators levels in POP patients.Multivariate Logistic regression was used to ana-lyze the influencing factors of POP occurrence.The receiver operating characteristic(ROC)curve was drawn to analyze the value of serum Smad7 and OPG alone and in combination(in parallel)in the diagnosis of POP.Results Compared with the control group,the levels of Smad7,β-CTX and OPN in the POP group were sig-nificantly increased(P＜0.05),while the levels of OPG,PⅠNP and OST were significantly decreased(P＜0.05).The Pearson correlation analysis results showed that serum Smad7 level in POP patients was positively correlated with β-CTX and OPN levels(r=0.395,0.426,P＜0.05),and negatively correlated with PⅠNP and OST levels(r=-0.421,-0.403,P＜0.05);serum OPG level was negatively correlated with β-CTX and OPN levels(r=-0.430,-0.399,P＜0.05),and positively correlated with PⅠNP and OST levels(r=0.387,0.414,P＜0.05).The elevated levels of Smad7,β-CTX and OPN were the risk factors for the POP oc-currence(P＜0.05),while the elevated levels of OPG,PⅠNP and OST were the protective factors for the POP occurrence(P＜0.05).The area under the ROC curve(AUC)for the serum Smad7 combined with OPG in diagnosing POP was 0.894,which was significantly greater than that of Smad7 and OPG alone(Z=3.652,3.773,P＜0.001).Conclusion Serum Smad7 level is higher and OPG level is lower in POP patients,and both levels are closely correlated with the bone metabolism in the patients,moreover the Smad7 combined with OPG has a high value for diagnosing POP.关键词
原发性骨质疏松症/Smad同源物7/骨保护素/骨代谢/诊断价值Key words
primary osteoporosis/Smad homolog 7/osteoprotegerin/bone metabolism/diagnostic value分类
临床医学引用本文复制引用
刘琴,邓玮..原发性骨质疏松症患者血清Smad7、OPG水平及其临床意义[J].检验医学与临床,2025,22(9):1189-1193,5.基金项目
重庆市科技局大健康重点项目(CSTC2021jscx-gksb-N0016). （CSTC2021jscx-gksb-N0016）
