检验医学与临床2025，Vol.22Issue(9)：1194-1198,1204,6.DOI:10.3969/j.issn.1672-9455.2025.09.008
苓桂术甘汤联合沙库巴曲缬沙坦钠片治疗尿毒症合并慢性心力衰竭的疗效以及对心肾功能指标的影响
Effect of Linggui Shugan Decoction combined with sacubitril valsartan sodium tablet in treating uremia complicating chronic heart failure and its influence on cardiac and renal function indexes
摘要
Abstract
Objective To explore the efficacy of Linggui Shugan Decoction combined with sacubitril valsar-tan sodium tablet in the treatment of uremia complicating chronic heart failure(CHF)and its impact on the cardiac and renal function indicators.Methods A total of 102 patients with uremia complicating CHF admit-ted and treated in this hospital from January 2020 to January 2024 were consecutively recruited as the research subjects and divided into two groups by the random number table method.The control group(51 cases)re-ceived the treatment of sacubitril valsartan sodium tablet for 3 months,while the observation group(51 cases)received the treatment of Linggui Shugan Decoction combined with sacubitril valsartan sodium tablet for 3 months.The efficacy,traditional Chinese medicine(TCM)syndrome scores,cardiac and renal function and quality of life after treatment in the two groups were evaluated.Results The total effective rate in the obser-vation group was 90.20％,which was higher than 64.71％in the control group(P＜0.05).After treatment,the left ventricular end-systolic diameter(LVSDD)and left ventricular end-diastolic diameter(LVEDD)of both groups were reduced compared with those before treatment(P＜0.05),the TCM syndrome scores,quali-ty of life scale(MLHFQ)scores,and serum N-terminal pro-brain natriuretic peptide(NT-proBNP),high-sen-sitivity troponin T(hsTnT),soluble ST2(sST2),blood urea nitrogen(BUN)and serum creatinine(Scr)lev-els were all lower than those before treatment(P＜0.05),while the left ventricular ejection fraction(LVEF)and estimated glomerular filtration rate(eGFR)were increased compared with those before treatment(P＜0.05).After treatment,LVSDD and LVEDD of the observation group were smaller than those of the control group(P＜0.05),the TCM syndrome scores,MLHFQ scores and serum NT-proBNP,hsTnT,sST2,BUN and Scr levels were all lower than those of the control group(P＜0.05),while LVEF and eGFR were higher than those of the control group(P＜0.05).Conclusion The Linggui Shugan Decoction combined with sacubi-tril valsartan sodium for the treatment of uremia complicating CHF can improve therapeutic efficacy,effec-tively enhance cardiac and renal function in the patients,and improve their quality of life.关键词
尿毒症/慢性心力衰竭/沙库巴曲缬沙坦钠/苓桂术甘汤/心功能Key words
uremia/chronic heart failure/sacubactril valsartan sodium/Linggui Shugan Decoction/cardiac function分类
临床医学引用本文复制引用
王春花,李梦瑜,黄敏,林海..苓桂术甘汤联合沙库巴曲缬沙坦钠片治疗尿毒症合并慢性心力衰竭的疗效以及对心肾功能指标的影响[J].检验医学与临床,2025,22(9):1194-1198,1204,6.基金项目
江苏省卫生健康委员会医学科研立项项目(Z2023037) （Z2023037）
江苏省苏州市科技发展计划项目(SYSD2019222). （SYSD2019222）
