检验医学与临床2025，Vol.22Issue(9)：1211-1215,5.DOI:10.3969/j.issn.1672-9455.2025.09.011
血清sIL-2R、HSP-70对儿童慢性浅表性胃炎的诊断价值及与病情的关系
Diagnostic value of serum sIL-2R and HSP-70 in children with chronic superficial gastritis and their relationship with disease condition
摘要
Abstract
Objective To analyze the diagnostic value of serum soluble interleukin-2 receptor(sIL-2R)and heat shock protein 70(HSP-70)levels in children patients with chronic superficial gastritis and their relation-ship with the disease severity and Helicobacter pylori(Hp)infection.Methods A total of 87 children patients with chronic superficial gastritis admitted and treated in Yulin Municipal Xingyuan Hospital from March 2022 to March 2024 were selected as the observation group.Eighty-seven healthy children undergoing physical ex-aminations in this hospital during the same period were chosen as the control group.According to the degree of inflammation of chronic superficial gastritis,the children in the observation group were divided into 36 cases in the mild group,28 cases in the moderate group and 23 cases in the severe group.Enzyme-linked immunosor-bent assay(ELISA)was used to detect the levels of serum sIL-2R and HSP-70 in the observation group and the control group.The 13 C breath test was used to detect the Hp infection status in the observation group,ac-cording to the test results,the children were divided into the Hp positive group and the Hp negative group.Spearman correlation was performed to analyze the correlation between the serum sIL-2R and HSP-70 levels with chronic superficial gastritis and the severity of the disease.Multivariate Logistic regression analysis was employed to analyze the influencing factors the children patients with chronic superficial gastritis.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum sIL-2R and HSP-70 for chronic superficial gastritis in children.Results The levels of serum sIL-2R and HSP-70 in the observation group were higher than those in the control group(P＜0.05).The levels of serum sIL-2R and HSP-70 in the moderate and severe group were higher than those in the mild group(P＜0.05);the levels of serum sIL-2R and HSP-70 in the severe group were higher than those in the moderate group(P＜0.05).The Spearman cor-relation analysis results showed that the levels of serum sIL-2R and HSP-70 in the children patients with chronic superficial gastritis were positively correlated with the severity of the disease(rs=0.536,0.512,both P＜0.05).The levels of serum sIL-2R and HSP-70 in the Hp positive group were higher than those in the Hp negative group(P＜0.05).The multifactorial Logistic regression analysis results indicated that high BMI,pa-rental education level of senior high school or below,parental Hp infection,lack of handwashing before meals and after defecation,absence of dedicated tableware,elevated sIL-2R level and increased HSP-70 level were the risk factors for chronic superficial gastritis in children(P＜0.05).The ROC curve analysis results revealed that the area under the curve(AUC)for the sIL-2R and HSP-70 combined diagnosis of chronic superficial gastritis in children was 0.953,which was significantly greater than that for sIL-2R(Z=2.123,P=0.034)and HSP-70 alone(Z=2.760,P=0.006).Conclusion The elevated levels of serum sIL-2R and HSP-70 in children patients with chronic superficial gastritis are associated with the severity of the disease and Hp infec-tion.The combination of sIL-2R and HSP-70 has a high diagnostic value for chronic superficial gastritis in children.关键词
可溶性白细胞介素-2受体/热休克蛋白-70/慢性浅表性胃炎/幽门螺旋杆菌/儿童Key words
soluble interleukin-2 receptor/heat shock protein 70/chronic superficial gastritis/Heli-cobacter pylori/children分类
医药卫生引用本文复制引用
柴航,何东,曹雷..血清sIL-2R、HSP-70对儿童慢性浅表性胃炎的诊断价值及与病情的关系[J].检验医学与临床,2025,22(9):1211-1215,5.基金项目
陕西省重点研发计划项目(2020SF-187). （2020SF-187）
