检验医学与临床2025，Vol.22Issue(9)：1216-1220,5.DOI:10.3969/j.issn.1672-9455.2025.09.012
口腔扁平苔藓患者血清ASH1L、Ang-2水平及临床意义
Serum ASH1L and Ang-2 levels in patients with oral lichen planus and their clinical significance
摘要
Abstract
Objective To explore the correlations between serum absent,small or homeotic 1-like protein(ASH1L)and angiopoietin-2(Ang-2)levels and with clinical signs,lesion degree and disease activity in the patients with oral lichen planus(OLP).Methods A total of 120 patients with OLP admitted and treated in this hospital from May 2020 to May 2023 were selected as the OLP group,and 119 healthy volunteers who un-derwent physical examinations in this hospital during the same period were selected as the control group.A-mong the OLP patients,39 cases were reticular type(reticular type group),48 cases were atrophic type(a-trophic type group)and 33 cases were erosive type(erosive type group).The serum ASH1L,Ang-2,interleu-kin(IL)-6 and tumor necrosis factor-α(TNF-α)levels of all research subjects were detected,and the correla-tions between serum ASH1L and Ang-2 levels with clinical sign score,RAE lesion score,REU disease activity score,IL-6 level and TNF-α level in OLP patients were analyzed.Results The serum Ang-2,IL-6 and TNF-αlevels in the OLP group were higher than those in the control group(P＜0.05),and the serum ASH1L level was lower than that in the control group(P＜0.05).The serum Ang-2,IL-6 and TNF-α levels and clinical sign score,RAE lesion score and REU disease activity score in the erosive type group were higher than those in the atrophic type group and reticular type group(P＜0.05),and the serum ASH1L level was lower than that in the atrophic type group and reticular type group(P＜0.05).The serum Ang-2,IL-6 and TNF-α levels and clinical sign score,RAE lesion score and REU disease activity score in the atrophic type group were higher than those in the reticular type group(P＜0.05),and the serum ASH1L level was lower than that in the re-ticular type group(P＜0.05).The serum ASH1L level in the OLP patients was negatively correlated with the clinical sign score,RAE lesion score,REU disease activity score,IL-6 and TNF-α levels(P＜0.05),and the Ang-2 level was positively correlated with the clinical sign score,RAE lesion score,REU disease activity score,IL-6 and TNF-α levels(P＜0.05).Conclusion The serum ASH1L level in OLP patients is decreased,and the Ang-2 level is increased.The ASH1L and Ang-2 levels are related to the clinical signs,lesion severity and disease activity of OLP patients.关键词
口腔扁平苔藓/ASH1L/血管生成素-2/白细胞介素-6/肿瘤坏死因子-αKey words
oral lichen planus/ASH1L/angiopoietin-2/interleukin-6/tumor necrosis factor-α分类
医药卫生引用本文复制引用
肖强,何浩,杨淼,尹莉,邓宇恬..口腔扁平苔藓患者血清ASH1L、Ang-2水平及临床意义[J].检验医学与临床,2025,22(9):1216-1220,5.基金项目
四川省卫生健康科研项目(20PJ110). （20PJ110）
