检验医学与临床2025，Vol.22Issue(9)：1221-1225,5.DOI:10.3969/j.issn.1672-9455.2025.09.013
血清HDAC1、ANGPTL3对慢性心力衰竭患者发生心血管事件的预测价值
Predictive value of serum HDAC1 and ANGPTL3 for cardiovascular event occurrence in patients with chronic heart failure
摘要
Abstract
Objective To explore the levels of serum histone deacetylase 1(HDAC1)and angiopoietin-like protein 3(ANGPTL3)in the patients with chronic heart failure and their predictive value for cardiovascular e-vents.Methods A total of 107 patients with chronic heart failure admitted and treated in the Department of Cardiology,Xi'an Municipal People's Hospital(Xi'an Municipal Fourth Hospital)from March 2022 to March 2024 were selected as the observation group and divided into the occurrence group and non-occurrence group according to the occurrence of cardiovascular events.The other 107 healthy volunteers undergoing physical ex-aminations in Xi'an Municipal People's Hospital(Xi'an Municipal Fourth Hospital)during the same period were selected as the control group.The levels of serum HDAC1 and ANGPTL3 were detected by enzyme-linked immunosorbent assay(ELISA).Multivariate Logistic regression analysis was used to analyze the influ-encing factors of cardiovascular events occurrence in the patients with chronic heart failure.The receiver oper-ating characteristic(ROC)curve was drawn to analyze the predictive value of serum HDAC1 and ANGPTL3 for cardiovascular events occurrence in the patients with chronic heart failure.Results Compared with the control group,the levels of serum HDAC1 and ANGPTL3 in the observation group were significantly in-creased(P＜0.05).During the follow-up period of chronic heart failure,41 cases had the cardiovascular events occurrence(occurrence group)and 66 cases had no cardiovascular events occurrence(non-occurrence group).The levels of serum HDAC1 and ANGPTL3 in the occurrence group were higher than those in the non-occur-rence group(P＜0.05).The disease course of chronic heart failure and the cardiac function grade had statisti-cally significantly difference between the occurrence group and non-occurrence group(P＜0.05).The results of multivariate Logistic regression analysis showed that the long disease course of chronic heart failure,cardiac function grade Ⅲ+Ⅳ,serum HDAC1 level increase and serum ANGPTL3 level increase all were the risk fac-tors for cardiovascular events occurrence in the patients with chronic heart failure(P＜0.05).The ROC curve analysis results showed that the area under the curve(AUC)of serum HDAC1 and ANGPTL3 combined pre-diction for the cardiovascular event occurrence in the patients with chronic heart failure was 0.903,which was significantly larger than AUC of the HDAC1 and ANGPTL3 prediction alone(P＜0.05).Conclusion The levels of serum HDAC1 and ANGPTL3 are elevated in the patients with chronic heart failure,and their combi-nation has a high predictive value for the occurrence of cardiovascular events.关键词
慢性心力衰竭/心血管事件/组蛋白脱乙酰化酶1/血管生成素样蛋白3/预测Key words
chronic heart failure/cardiovascular events/histone deacetylase 1/angiopoietin-like pro-tein 3/prediction分类
临床医学引用本文复制引用
邓盼,吴飞妮..血清HDAC1、ANGPTL3对慢性心力衰竭患者发生心血管事件的预测价值[J].检验医学与临床,2025,22(9):1221-1225,5.基金项目
陕西省重点研发计划项目(2020sf-261). （2020sf-261）
