检验医学与临床2025，Vol.22Issue(9)：1226-1230,1235,6.DOI:10.3969/j.issn.1672-9455.2025.09.014
血清Th1/Th2细胞因子联合肿瘤标志物诊断HR-HPV阳性宫颈癌的价值分析
Analysis on value of serum Th1/Th2 cytokines combined with tumor markers in diagnosis of high-risk HPV positive cervical cancer
摘要
Abstract
Objective To analyze the value of serum helper T cell 1(Th1)/helper T cell 2(Th2)cytokines combined with tumor markers in diagnosing high-risk human papillomavirus(HR-HPV)positive cervical cancer.Methods A total of 49 cases of HR-HPV positive cervical cancer in this hospital from January 2019 to June 2023 were selected as the study group,and 49 cases of HR-HPV positive cervical benign diseases in the same age group during the same period were selected as the control group.The basic data,serum Th1/Th2 cy-tokines[interleukin-10(IL-10),interleukin-6(IL-6),interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α)],tumor markers[squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen 199(CA199),cytoker-atin 19 fragment antigen 21-1(CYFRA21-1)]levels were compared between the two groups.The serum Th1/Th2 cytokines were compared among the patients with different pathological characteristics in the study group.The correlation between serum Th1/Th2 cytokines and tumor markers levels in HR-HPV positive cer-vical cancer patients was analyzed by Pearson correlation.The receiver operating characteristic(ROC)curve was drawn to analyze the value of serum Th1/Th2 cytokines and tumor markers for diagnosing HR-HPV pos-itive cervical cancer.Results The serum IL-10,IL-6,IFN-γ,TNF-α,SCC-Ag,CA199 and CYFRA21-1 levels in the study group were higher than those in the control group(P＜0.05).The levels of serum IL-10,IL-6,IFN-γ and TNF-α in the patients with FIGOstage Ⅲ-Ⅳ were higher than those in the patients with stageⅠ-Ⅱ,and the levels of serum IL-10,IL-6,IFN-γ and TNF-α in the patients with myometrial invasion depth ≥1/2 were higher than those in the patients with myometrial invasion depth＜1/2(P＜0.05).The se-rum IL-10,IL-6,IFN-γ and TNF-α levels in the patients with HR-HPV positive cervical cancer were positively correlated with the SCC-Ag,CA199 and CYFRA21-1 levels(P＜0.05);the area under the curve(AUC)of se-rum IL-10,IL-6,IFN-γ,and TNF-α for single item diagnosing HR-HPV positive cervical cancer was 0.809,0.773,0.801 and 0.794,respectively.AUC of SCC-Ag,CA199,and CYFRA21-1 alone for the diagnosis of HR-HPV positive cervical cancer were 0.831,0.728 and 0.789,respectively.AUC of serum IL-10,IL-6,IFN-γ,TNF-α,SCC-Ag,CA199 and CYFRA21-1 for jointly diagnosing HR-HPV positive cervical cancer was 0.927,which was greater than AUC of each indicator alone(Z=2.116,2.690,2.341,2.565,1.957,3.351,2.631,P=0.034,0.007,0.019,0.010,0.039,0.001,0.009).Conclusion Serum IL-10,IL-6,IFN-γ,TNF-αcould serve as auxiliary diagnostic indicators of HR-HPV positive cervical cancer,which are combined with SCC-Ag,CA199 and CYFRA21-1 could improve the diagnostic efficiency.关键词
宫颈癌/高危型人乳头瘤病毒/细胞因子/肿瘤标志物/诊断Key words
cervical cancer/high-risk human papillomavirus/cytokines/tumor markers/diagnosis分类
医药卫生引用本文复制引用
陈秀英,陈娜,李晓丹,崔建涛,张士表..血清Th1/Th2细胞因子联合肿瘤标志物诊断HR-HPV阳性宫颈癌的价值分析[J].检验医学与临床,2025,22(9):1226-1230,1235,6.基金项目
河北省中医药管理局中医药类科研计划课题(2020486). （2020486）
