检验医学与临床2025，Vol.22Issue(9)：1231-1235,5.DOI:10.3969/j.issn.1672-9455.2025.09.015
慢性酒精依赖患者血清HMGB1、HDAC2与认知功能损害的关系研究
Study on relationship between HMGB1 and HDAC2 with cognitive functional impairment in patients with chronic alcohol dependence
摘要
Abstract
Objective To investigate the relationship between serum high mobility group protein B1(HMGB1)and histone deacetylase 2(HDAC2)with the cognitive functional impairment in the patients with chronic alcohol dependence(CAD).Methods Sixty-two patients with CAD admitted and treated in this hospi-tal from February 2021 to February 2024 were selected as the impairment group,58 cases of CAD without complicating cognitive functional impairment during the same period were selected as the non-impairment group and 100 healthy individuals undergoing physical examination during the same period were selected as the control group.The levels of serum HMGB1 and HDAC2 were compared among the groups.Multivariate Logistic regression was applied to analyze the influencing factors of cognitive functional impairment in CAD patients.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum HMGB1 and HDAC2 levels for cognitive functional impairment in CAD patients.Results Compared with the control group,the levels of serum HMGB1 and HDAC2 in the impairment group and non-impairment group were significantly increased(P＜0.05).Compared with the non-impairment group,the levels of serum HMGB1 and HDAC2 in the impairment group were significantly increased(P＜0.05).The duration of drink-ing and disease duration in the impairment group were significantly longer than those in the non-impairment group(P＜0.05),the daily alcohol intake amount in the impairment group was higher than that in the non-impairment group(P＜0.05).The multivariate Logistic regression analysis results showed that the long dis-ease duration,large daily alcohol intake,serum HMGB1 level increase and serum HDAC2 level increase were the risk factors for the cognitive functional impairment occurrence in CAD patients(P＜0.05).The area un-der the curve(AUC)of serum HMGB1 and HDAC2 levels for diagnosing the cognitive functional impairment in CAD patients was 0.836 and 0.783,respectively.AUC of the two combination for diagnosing was 0.907,which was significantly higher than that of HMGB1(Z=2.523,P=0.012)and HDAC2(Z=3.565,P＜0.001)alone.Conclusion The serum HMGB1 and HDAC2 levels in CAD patients are significantly up-regula-ted,moreover which all are the influencing factors for cognitive functional impairment of the patients.The combination of the two has high diagnostic value for cognitive functional impairment in CAD patients.关键词
慢性酒精依赖/高迁移率族蛋白B1/组蛋白脱乙酰酶2/认知功能损害/蒙特利尔认知评估量表Key words
chronic alcohol dependence/high mobility group protein B1/histone deacetylase 2/cog-nitive functional impairment/Montreal Cognitive Assessment Scale分类
医药卫生引用本文复制引用
白景林,侯学静,成瑶,刘亚..慢性酒精依赖患者血清HMGB1、HDAC2与认知功能损害的关系研究[J].检验医学与临床,2025,22(9):1231-1235,5.基金项目
河北省医学科学研究课题计划项目(20221497). （20221497）
