检验医学与临床2025，Vol.22Issue(9)：1246-1250,1256,6.DOI:10.3969/j.issn.1672-9455.2025.09.018
血清IL-17、VILIP-1及8-OHdG对老年股骨粗隆间骨折患者发生术后认知功能障碍的预测价值
Predictive value of serum IL-17,VILIP-1 and 8-OHdG in postoperative cognitive impairment occurrence in elderly patients with intertrochanteric femoral fracture
摘要
Abstract
Objective To investigate the predictive value of serum interleukin-17(IL-17),visinin-like pro-tein 1(VILIP-1)and 8-hydroxydeoxyguanosine(8-OHdG)for postoperative cognitive dysfunction(POCD)occurrence in elderly patients with intertrochanteric femoral fractures(IFF)to provide reference for clinical diagnosis and treatment.Methods A total of 87 elderly patients with IFF admitted and treated in the orthope-dic department of Nanjing Tongren Hospital from January 2020 to December 2023 were selected.The POCD status of the patients was evaluated by the Montreal Cognitive Assessment(MoCA)on postoperative 7 d.The patients were divided into the POCD group(MoCA score＜26 points)and non-POCD group(MoCA score 26 points).The serum IL-17,VILIP-1 and 8-OHdG levels before surgery,on postoperative 1,3 d were com-pared between the two groups,and the predictive value of serum IL-17,VILIP-1 and 8-OHdG for POCD in elderly patients with IFF was analyzed.The risk degree of different serum IL-17,VILIP-1 and 8-OHdG levels on POCD occurrence in elderly patients with IFF was analyzed,which was represent by the relative risk(RR).Results There were 26 cases in the POCD group and 61 cases in the non-POCD group.The results of repeated measures analysis of variance showed that the serum IL-17,VILIP-1 and 8-OHdG at different times in the two groups had the time effects,intergroup effects and interaction effects of,and the differences were statistically significant(P＜0.05).The serum IL-17,VILIP-1 and 8-OHdG levels on postoperative 1,3 d in the two groups were higher than those before surgery(P＜0.02),and the serum IL-17,VILIP-1 and 8-OHdG levels on postoperative 3 d in the two groups were higher than those on postoperative 1 d(P＜0.02).The re-sults of multivariate analysis of variance showed that the serum IL-17,VILIP-1 and 8-OHdG levels on postop-erative 1,3 d in the POCD group were higher than those in the non-POCD group(P＜0.05).The area under the curve(AUC)of the three indicators combination on postoperative 1,3 d for predicting POCD occurrence in elderly patients with IFF were 0.925(95％CI:0.848-0.970)and 0.945(95％CI:0.874-0.983),respec-tively.The risk of POCD occurrence in the elderly IFF patients with high levels of serum IL-17,VILIP-1 and 8-OHdG on postoperative 1 d,3 d were several times higher than that in the patients with low levels of IL-17,VILIP-1 and 8-OHdG(postoperative 1 d:RR=2.901,4.903,3.258,P＜0.001;postoperative 3 d:RR=6.171,6.429,4.298,P＜0.001).Conclusion The serum IL-17,VILIP-1 and 8-OHdG levels are closely relat-ed to the POCD occurrence in elderly patients with IFF and could serve as the markers for predicting POCD.关键词
股骨粗隆间骨折/视椎蛋白样蛋白1/白细胞介素-17/8-羟脱氧鸟苷/老年/认知功能障碍Key words
intertrochanteric femoral fracture/osteopontin-like protein 1/interleukin-17/8-hydroxydeoxyguanosine/elderly/cognitive impairment分类
医药卫生引用本文复制引用
袁之木,刘建民,孙文建,邱燕森..血清IL-17、VILIP-1及8-OHdG对老年股骨粗隆间骨折患者发生术后认知功能障碍的预测价值[J].检验医学与临床,2025,22(9):1246-1250,1256,6.基金项目
2021年度南京市卫生科技发展专项资金项目(YKK21247) （YKK21247）
江苏省优势学科建设工程项目(YSHL2001-1241). （YSHL2001-1241）
