检验医学与临床2025，Vol.22Issue(9)：1251-1256,6.DOI:10.3969/j.issn.1672-9455.2025.09.019
血小板参数和淋巴细胞亚群对儿童血小板减少症病因分析的意义
Significance of platelet parameters and lymphocyte subsets in etiology analysis of thrombocytopenia in children
摘要
Abstract
Objective To investigate the differences and significance of platelet parameters and lymphocyte subsets in children patients with thrombocytopenia of different etiologies.Methods The children patients with thrombocytopenia visited in this hospital from January 2021 to December 2023 were selected as the re-search subjects,including 194 cases in the neonatal thrombocytopenia(NTP)group,87 cases in the acute leu-kemia(AL)group,103 cases in the immune thrombocytopenia(ITP)group,22 cases in the aplastic anemia(AA)group,29 cases in the extramedullary tumors group,14 cases in the systemic lupus erythematosus(SLE)group and 130 cases in the infectious diseases group.Meanwhile 200 healthy children undergoing physi-cal examinations in this hospital during the same period were selected as the control group.The platelet pa-rameters[mean platelet volume(MPV),platelet count(PLT),platelet distribution width(PDW)and plateletcrit(PCT)]were retrospectively analyzed and compared among the groups.The lymphocyte subsets levels were compared among 45 cases in the AL group,65 cases in the ITP group,48 cases in the infectious diseases group and 94 cases in the control group.Results MPV,PLT,PDW and PCT of the NTP group,AL group and infectious diseases group had statistically significant differences compared with those of the control group(P＜0.05).MPV,PLT and PCT in the ITP group,extramedullary tumor group and SLE group,and PLT and PCT in the AA group had statistically significant differences compared with those of the control group(P＜0.05),while the PDW in the ITP group,extramedullary tumor group,SLE group and AA group was not significantly different compared with the control group(P＞0.05).MPV of the AA group and AL group was lower than that of the NTP group,ITP group,SLE group and infectious diseases group(P＜0.05),which in the AA group was the lowest.PLT in the ITP group was lower than that in the NTP group,infectious diseases group,AL group and extramedullary tumour group(P＜0.05),PCT was lower than that in the NTP group and infectious diseases group(P＜0.05).PLT and PCT in the AA group were lower than those in the NTP group and infectious diseases group(P＜0.05).PCT in the AL group had statistically sig-nificant difference compared with that in the NTP group(P＜0.05).The PDW level in the NTP group was higher than that in the AL group,ITP group,AA group,SLE group and infectious diseases group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in MPV,PLT,PDW and PCT between the AL group and extramedullary tumor group(P＞0.05).There were no sta-tistically significant differences in MPV,PLT,PDW and PCT among the ALL group,AML group and extr-amedullary tumor group(P＞0.05).The proportions of CD3+T cells,CD3+CD4+T cells and CD3-CD16+CD56+NK cells in the infectious diseases group were lower than those in the control group,while the propor-tion of CD3-CD19+B lymphocytes was higher than that in the control group,and the differences were statisti-cally significant(P＜0.05).The proportions of CD3+CD4+T cells and CD3-CD16+CD56+NK cells in the AL group were lower than those in the control group(P＜0.05).The proportion of CD3-CD16+CD56+NK cells in the ITP group was lower than that in the control group(P＜0.05).The proportions of CD3+T cells,CD3+CD4+T cells and CD3-CD19+B lymphocytes had statistically significantly difference between the ITP group and infectious diseases group(P＜0.05).The proportion of CD3+CD4+T cells and the CD4+/CD8+T cell ra-tio in the AL group were statistically significantly different from those in the ITP group(P＜0.05).Conclu-sion There are differences in platelet parameters and lymphocyte subsets among children patients with thrombocytopenia of different etiologies.Utilizing the platelet parameters and lymphocyte subsets could pre-liminarily judge the cause of thrombocytopenia and has certain clinical significance for the early diagnosis of thrombocytopenia.关键词
血小板参数/淋巴细胞亚群/儿童/血小板减少症/病因Key words
platelet parameters/lymphocyte subpopulation/children/thrombocytopenia/etiology分类
医药卫生引用本文复制引用
荣成智,唐文庭,李明艺,胡雪桦,兰访..血小板参数和淋巴细胞亚群对儿童血小板减少症病因分析的意义[J].检验医学与临床,2025,22(9):1251-1256,6.基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20200745) （Z20200745）
广西医疗卫生适宜技术开发与推广应用项目(S2023040). （S2023040）
