临床眼科杂志2025，Vol.33Issue(2)：121-126,6.DOI:10.3969/j.issn.1006-8422.2025.02.006
视网膜静脉阻塞黄斑水肿患者血清ET-1、NT-proBNP、CTRP9表达与病情及预后的关系
Relationship between serum ET-1,NT-proBNP,CTRP9 expression with disease condition and prognosis in patients with retinal vein occlusion combined with macular edema
摘要
Abstract
Objective To investigate the expression of serum endothelin-1(ET-1),N-terminal pro-B-type natri-uretic peptide(NT-proBNP),complement 1q/tumor necrosis factor related protein 9(CTRP9)in patients with retinal vein occlusion(RVO)combined with macular edema,and to analyze the relationship between serum ET-1,NT-proBNP,CTRP9 with disease condition and prognosis.Methods A retrospective case-control study.A total of 106 patients(106 eyes)with macular edema caused by RVO who visited the ophthalmology department of our hospital from June 2020 to June 2023 were selected as the case group.In addition,50 patients with simple RVO who visited the same period were re-garded as the simple group,and 50 healthy eye patients who visited the same period were as the control group.Patients in the case group were grouped based on the degree of macular edema and prognosis,and serum levels of ET-1,NT-proBNP,and CTRP9 were compared.Spear'man method was applied to analyze the correlation between serum ET-1,NT-proBNP,CTRP9 and the degree of macular edema in the case group.ROC was applied to analyze the predictive value of serum ET-1,NT-proBNP,and CTRP9 for poor prognosis in the case group.Results There were obvious differences in ET-1,NT-proBNP,and CTRP9 among the case group,simple group,and control group.In terms of ET-1 and NT-proBNP,the case group>simple group>control group,and in terms of CTRP9,the case group<simple group<control group(all P<0.05).The levels of ET-1,NT-proBNP,and CTRP9 varied among patients of different degrees in the case group.In terms of ET-1 and NT-proBNP,the severe group>the moderate group>the mild group,while in terms of CTRP9,the severe group<the moderate group<the mild group(all P<0.05).ET-1 and NT-proBNP were positively correlated with the de-gree of macular edema(r=0.436,r=0.471),while CTRP9 was negatively correlated with the degree of macular edema(r=-0.502)(all P<0.05).The ET-1 and NT-proBNP levels in the poor prognosis group were higher than those in the good prognosis group,while CTRP9 level was lower than that in the good prognosis group(all P<0.05).The AUC and sensitiv-ity of serum ET-1,NT-proBNP,and CTRP9 in predicting poor prognosis of patients in the case group were lower than those of the three combined prediction model,with Zcombination-ET-1=2.823,Zcombination-NT-proBNP=2.146,and Zcombination-CTRP9=2.120(all P<0.05).Conclusions Patients with RVO combined with macular edema have higher levels of serum ET-1 and NT-proBNP,while lower level of CTRP9.The levels of ET-1,NT-proBNP,and CTRP9 are related to the degree of macular edema and prognosis.Combined detection of serum levels can effectively predict the prognosis.关键词
视网膜静脉阻塞/黄斑水肿/内皮素1/N末端B型利钠肽原/补体1q/肿瘤坏死因子相关蛋白9/病情/预后Key words
Retinal vein occlusion/macular edema/Endothelin 1/N-terminal pro-B-type natriuretic peptide/Complement 1q/tumor necrosis factor related protein 9/Disease condition/Prognosis引用本文复制引用
李成茂,李维娜..视网膜静脉阻塞黄斑水肿患者血清ET-1、NT-proBNP、CTRP9表达与病情及预后的关系[J].临床眼科杂志,2025,33(2):121-126,6.基金项目
泉州市2021年医疗卫生领域指导性科技计划项目[泉科(2021)150号-166] （2021）
