临床误诊误治2025，Vol.38Issue(9)：53-60,8.DOI:10.3969/j.issn.1002-3429.2025.09.009
糖尿病足创面多重耐药微生物感染的危险因素Meta分析
Meta-analysis of Risk Factors for Multidrug-Resistant Organism Infection in Patients with Diabetic Foot Wounds
摘要
Abstract
Objective To investigate the risk factors of multi-drug resistant organism(MDRO)infection in patients with diabetic foot wound.Methods A systematic search was conducted on Chinese Journal Full-Text Database CNKI,Wan-fang Data Resource System(Wanfang),Chinese Biomedical Literature Database(CBM),VIP database,PubMed,Web of Science,EmBase,The Cochrane Library,Ovid and Proquest for all literature on MDRO risk factors for diabetic foot wounds from inception until September 3,2024.Literature screening and data extraction were carried out according to the established criteria for literature inclusion and exclusion.Data such as the number of cases in the included literature and the risk factors of MDRO infection were extracted,and the risk factors of MDRO infection in patients with diabetic foot wound were combined and analyzed.Newcastle-Ottawa Scale(NOS)was used to evaluate the quality of research literature,and medium and high quality literature were selected.Meta-analysis was performed using RevMan 5.3 software.Results Finally,19 literatures were included,including 2 cohort studies and 17 case-control studies.A total of 8 638 cases were included,including 1 583 cases in the MDRO group and 7 055 cases in the non-MDRO group.The literature quality was medium to high.The results of Meta-analysis showed that osteomyelitis[OR=3.23,95%CI(2.62,3.99)],times of hospitalization for the same infection wound＞2 times/year[OR=2.60,95%CI(2.03,3.33)],antibiotic use history[OR=2.01,95%CI(1.80,2.25)],neuroischemic ulcer[OR=1.25,95%CI(1.16,1.34)],wound course[OR=1.34,95%CI(1.08,1.66)]and wound area[OR=1.48,95%CI(1.03,2.14)]were risk factors for MDRO infection in patients with diabetic foot wound(P＜0.05,P＜0.01).Conclusion Osteomyelitis,times of hospitalization for the same infection wound＞2 times/year,history of antibiotic application,neuroischemic ulcer,wound area and wound course are the main risk factors for MDRO infection in patients with diabetic foot wound.If these risk factors are present in the clinical diagnosis and treatment of diabetic foot,they should be corrected in time to promote wound healing.关键词
糖尿病足/多重耐药微生物/危险因素/骨髓炎/抗生素应用史/神经缺血性溃疡/创面/Meta分析Key words
Diabetic foot/Multidrug-resistant organism/Risk factors/Osteomyelitis/History of antibiotic use/Neu-roischemic ulcer/Wound/Meta-analysis分类
临床医学引用本文复制引用
毛森淼,张建萌,杨少玲,程琪..糖尿病足创面多重耐药微生物感染的危险因素Meta分析[J].临床误诊误治,2025,38(9):53-60,8.基金项目
河北省卫生健康委员会指导性课题(20240696) （20240696）
