临床误诊误治2025，Vol.38Issue(9)：82-86,103,6.DOI:10.3969/j.issn.1002-3429.2025.09.014
极早产儿血清25-羟维生素D水平不足的影响因素及与坏死性小肠结肠炎的关系
Factors Influencing Insufficient Serum 25-hydroxyvitamin D Levels in Ex-tremely Premature Infants and Their Relationship with Necrotizing Entero-colitis
摘要
Abstract
Objective To analyze the influencing factors of insufficient serum 25-hydroxyvitamin D[25-(OH)D]levels in extremely premature infants,and to investigate the relationship between serum 25-(OH)D levels and necrotizing en-terocolitis(NEC).Methods A total of 200 extremely premature infants admitted from May 2018 to May 2023 were selected.Serum 25-(OH)D levels were measured within 2 h after birth in the infants,and the incidence of insufficient serum 25-(OH)D levels was calculated.Infants with insufficient serum 25-(OH)D levels were included in the insufficient group,while infants with normal serum 25-(OH)D levels were included in the normal group.Clinical data of the two groups were compared,and factors influencing insufficient serum 25-(OH)D levels were analyzed.The incidence of NEC within 28 d af-ter birth was compared between the two groups,and the serum 25-(OH)D levels were compared between infants with and without NEC.The value of serum 25-(OH)D levels in predicting NEC was analyzed.Results The insufficient rate of serum 25-(OH)D levels was 68.50%(137/200).The incidence of maternal gestational diabetes mellitus(GDM)and gestational hypertension(GH)of extremely preterm infants in insufficient serum 25-(OH)D level group was higher than that in the nor-mal group,and the prenatal serum 25-(OH)D levels were lower than those in the normal group(P＜0.01).The birth rate of extremely preterm infants in the insufficient serum25-(OH)D level group during winter and spring[59.12%(81/137)]was higher than that in the normal group[31.75%(20/63)],with a significant difference(P＜0.01).Maternal GDM,GH,prenatal serum 25-(OH)D levels,and the birth season of extremely preterm infants were all influencing factors of insuf-ficient serum 25-(OH)D levels(P＜0.01).The incidence of NEC in the insufficient serum 25-(OH)D level group[17.52%(24/137)]was higher than that in the normal group[4.76%(3/63)],with a significant difference(P＜0.05).The serum 25-(OH)D levels of extremely preterm infants with NEC were lower than those without NEC(P＜0.01).The area under the receiver operating characteristic curve for predicting the occurrence of NEC in extremely preterm infants based on se-rum 25-(OH)D levels was 0.850(95%CI:0.792,0.896),with a sensitivity of 92.59%and a specificity of 71.10%.Conclusion The influencing factors of insufficient serum 25-(OH)D levels in extremely premature infants include maternal GDM,GH,prenatal serum 25-(OH)D levels,and the birth season of the extremely premature infants.Furthermore,insuffi-cient serum 25-(OH)D levels are closely related to the occurrence of NEC.关键词
极早产儿/25-羟维生素D/坏死性小肠结肠炎/妊娠期糖尿病/妊娠期高血压/受试者工作特征/曲线下面积/预测Key words
Extremely premature infants/25-hydroxyvitamin D/Necrotizing enterocolitis/Gestational diabetes/Ges-tational hypertension/Receiver operating characteristic/Area under the curve/Prediction分类
医药卫生引用本文复制引用
张敏,杨立,王文秀,姚秋雨..极早产儿血清25-羟维生素D水平不足的影响因素及与坏死性小肠结肠炎的关系[J].临床误诊误治,2025,38(9):82-86,103,6.基金项目
北京市卫生健康委员会北京市卫生健康科技成果和适宜技术推广项目(BHTPP202019) （BHTPP202019）
北京市通州区科技计划项目(KJ2022CX055) （KJ2022CX055）
