器官移植2025，Vol.16Issue(3)：350-358,9.DOI:10.12464/j.issn.1674-7445.2025099
2024年全球肝移植研究年度盘点——技术突破、精准管理与未来挑战
Annual review of global liver transplantation research in 2024:technological breakthroughs,precision management and future challenges
摘要
Abstract
In recent years,significant progress has been made in the field of liver transplantation in terms of donor expansion,technological innovation and perioperative management.Machine perfusion technology,through dynamic repair and assessment of donor liver quality,can effectively reduce postoperative complications and increase the utilization rate of marginal donor livers.The optimization of split liver transplantation technology combined with normothermic perfusion further alleviates the shortage of donors,but its promotion is still limited by technical barriers.Xenotransplantation has achieved preclinical breakthroughs in the field of genetically modified pig livers,but ethical and immune barrier issues need to be urgently resolved.In the field of liver cancer liver transplantation,the focus is on neoadjuvant treatment with immune checkpoint inhibitors and the development of recurrence prediction models,which promotes precise treatment.For perioperative management,the optimization of individualized immunosuppressive regimens,artificial liver support,and strategies for the prevention and control of vascular complications has significantly improved patients'survival rates.Personalized treatment for children,elderly recipients,and recipients with multiple comorbidities provides new ideas for liver transplantation in special populations.In the future,liver transplantation research may focus on the integration of multidisciplinary approaches,individualized treatment and emerging technologies to advance the global liver transplantation cause to new heights.关键词
肝移植/供肝来源/机械灌注/劈离式肝移植/异种移植/肝癌肝移植/围手术期管理/并发症防控Key words
Liver transplantation/Donor liver source/Machine perfusion/Split liver transplantation/Xenotransplantation/Liver cancer liver transplantation/Perioperative management/Complication prevention and control分类
医药卫生引用本文复制引用
蒋勇,冯啸,刘炜,杨扬..2024年全球肝移植研究年度盘点——技术突破、精准管理与未来挑战[J].器官移植,2025,16(3):350-358,9.基金项目
国家重点研发计划(2024YFA1107200) （2024YFA1107200）
国家自然科学基金(U24A20655、82172585) （U24A20655、82172585）
广州市科技计划项目(2024A03J0273) （2024A03J0273）
