环境与职业医学2025，Vol.42Issue(3)：342-348,7.DOI:10.11836/JEOM24310
拟除虫菊酯类农药暴露与学龄期儿童肺功能的相关性
Association between pyrethroid insecticide exposure and pulmonary function among school-aged children
摘要
Abstract
[Background]Prior epidemiological studies suggest that exposure to pyrethroid insecticides may adversely affect children's respiratory health.However,only limited studies are currently available on this topic in China. [Objective]To explore the association between exposure to pyrethroid insecticides and pul-monary function in children in Shanghai. [Methods]From August 2019 to January 2020,a cross-sectional study was conducted,recruiting 163 healthy school-aged children(aged 5-12 years)from Shanghai Children's Hospital,Shanghai Jiao Tong University School of Medicine.Basic information,including age,height,weight,and family income,was collected.Urine samples from the children were collected and were analyzed for the levels of three pyrethroid insecticide metabolites:3-phenoxybenzoic acid(3-PBA),cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclo-propane carboxylic acid(CDCCA),and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid(TDCCA).Gas chromatography-tandem mass spectrometry(GC-MS/MS)was used for the analysis.Spirometry was used to assess pulmonary function and recorded fol-lowing parameters:peak expiratory flow(PEF),forced expiratory flow between the 25th and 75th percentiles of forced vital capacity(FEF25-75),forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC.Multiple linear regression and restricted cubic spline models were used to evaluate the associations between urinary pyrethroid insecticide metabolite levels and pulmonary function parameters. [Results]The study included 163 school-aged children,with an average age of(7.04±2.08)years and an average body mass index(BMI)of(16.04±2.72)kg·m-2;75(46.01％)of the participants were boys.The detection rates of 3-PBA,TDCCA,and CDCCA in urine were 85.28％,17.79％,and 4.91％,respectively.The median creatinine-adjusted 3-PBA concentration was 0.150 μg·g-1.After adjusting for con-founders such as height,BMI,sex,age,delivery mode,annual family income,and maternal education level,the multiple linear regression model showed that urinary 3-PBA levels were negatively associated with both FVC[β=-0.030,95％confidence interval(CI):-0.058,-0.003;P=0.031]and FEV1(β=-0.032,95％CI:-0.064,0.000;P=0.04998).The final restricted cubic spline model showed a nonlinear asso-ciation between urinary 3-PBA levels and FVC,FEV1,PEF,and FEF25-75(P for nonlinear＜0.05;P for overall＜0.05). [Conclusion]The level of pyrethroid insecticide exposure in school-aged children in Shanghai is relatively high.The urinary 3-PBA concen-tration is negatively associated with pulmonary function,indicating potential adverse effects of pyrethroid insecticide exposure on respi-ratory health of school-aged children.关键词
学龄期儿童/拟除虫菊酯类农药/3-苯氧基苯甲酸/肺功能/第1秒用力呼气容积/用力肺活量Key words
school-aged child/pyrethroid insecticide/3-phenoxybenzoic acid/pulmonary function/forced expiratory volume in one second/forced vital capacity分类
医药卫生引用本文复制引用
钱丽花,户宜,胡培培,丁国栋..拟除虫菊酯类农药暴露与学龄期儿童肺功能的相关性[J].环境与职业医学,2025,42(3):342-348,7.基金项目
国家自然科学基金面上项目(81972991) （81972991）
上海市科学技术委员会青年扬帆计划项目(19YF1440900) （19YF1440900）
