器官移植2025，Vol.16Issue(3)：482-488,7.DOI:10.12464/j.issn.1674-7445.2025002
慢加急性肝衰竭肝移植预后评估
Prognostic evaluation of liver transplantation for acute-on-chronic liver failure
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is an acute deterioration of liver function occurring on the basis of chronic liver disease,accompanied by failure of the liver and extrahepatic organs,and is associated with a high short-term mortality rate.Liver transplantation is the only curative treatment for patients with ACLF.However,the shortage of donor livers and limitations of the organ allocation system mean that only a minority of patients can receive transplants.The current organ allocation system based on the model for end-stage liver disease(MELD)score may underestimate the urgency of liver transplantation for ACLF patients.Therefore,it is urgent to develop better assessment tools to determine which ACLF patients are most likely to benefit from liver transplantation.This article reviews the current mainstream definitions of ACLF,the selection of candidates for liver transplantation in ACLF,and the prognostic scoring systems for liver transplantation in ACLF,both domestically and internationally,in order to provide a reference for the prognostic assessment of liver transplantation in ACLF patients.关键词
肝移植/慢加急性肝衰竭/器官衰竭/终末期肝病模型评分/预后/静态评估/动态评估/机器学习Key words
Liver transplantation/Acute-on-chronic liver failure/Organ failure/Model for end-stage liver disease score/Prognosis/Static assessment/Dynamic assessment/Machine learning分类
医药卫生引用本文复制引用
赖曼,徐曼曼,王鑫,栗光明,陈煜..慢加急性肝衰竭肝移植预后评估[J].器官移植,2025,16(3):482-488,7.基金项目
北京市高层次公共卫生技术人才建设项目(学科带头人-01-12) （学科带头人-01-12）
北京市医院管理中心"登峰"计划专项经费资助项目(DFL20221501) （DFL20221501）
