环境与职业医学2025，Vol.42Issue(4)：408-414,419,8.DOI:10.11836/JEOM24364
2019-2023年大气污染物对儿童哮喘的影响
Impacts of ambient air pollutants on childhood asthma from 2019 to 2023:An analysis based on asthma outpatient visits of Nanjing Children's Hospital
摘要
Abstract
[Background]Asthma poses a serious threat to children's growth,development,and mental health,thus there has been an increasing focus on the control of asthma morbidity in children and the assessment of its risk factors.A growing body of research has found that exposure to ambient air pollutants an significatly increase the risk of childhood asthma. [Objective]To understand the changes of ambient air pollutant concentrations in Nanjing and asthma outpatient visits to Nanjing Children's Hospital,and to quantitatively analyze the effects of exposure to different ambient air pollutants on children's asthma outpatient visits. [Methods]Daily data of ambient air pollutants fine particulate matter(PM2.5),inhalable particle(PM10),sulfur dioxide(SO2),nitrogen dioxide(NO2),carbon monoxide(CO),ozone(O3),meteorological factors(air temperature&relative humidity),and outpatient visits due to asthma in the hospital from January 1,2019 to December 31,2023 were collected,and a generalized additive model based on quasi poisson distributions was used to quantitatively an-alyze the short-term effects of ambient air pollutant exposure on outpatient visits due to asthma in the hospital. [Results]The annual average concentrations of PM2.5,PM10,SO2,and NO2 in Nanjing from 2019 to 2023 did not exceed the national lim-its.For single-day lagged effects,the single-pollutant model showed that the effects of PM2.5,PM10,NO2,and CO on children's asthma outpatient visits were greatest for every 10 units increase at lag0,with excess risk(ER)of 1.39%(95%CI:0.65%,2.14%),1.46%(95%CI:0.97%,1.95%),5.46%(95%CI:4.36%,6.57%),and 0.18%(95%CI:0.11%,0.26%),respectively,and SO2 reached the maximum effect at lag1,with an ER of 23.15%(95%CI:13.57%,33.53%)for each 10 units increase in concentration.Different pollutants reached their maximum cumulative lag effects at different time.The PM10,PM2.5,SO2,NO2,and CO showed the largest cumulative lag effects at lag01,lag01,lag02,lag02,and lag03,respectively,with ERs of 1.35%(95%CI:0.77%,1.92%),0.96%(95%CI:0.10%,1.83%),28.50%(95%CI:15.49%,42.98%),6.92%(95%CI:5.53%,8.33%),and 0.31%(95%CI:0.20%,0.42%),respectively.The influences of PM2.5 and PM10 on outpatient visits due to asthma in the hospital became more pronounced with advancing age,while the associations with NO₂,SO₂,and CO were weakened as children grew older. [Conclusion]Ambient air pollutants(PM2.5,PM10,SO2,NO2,CO)can increase childhood asthma visits,and different pollutants have varied effects on the number of asthmatic children's visits at different ages.关键词
大气污染物/儿童/哮喘/门诊就诊量/滞后效应Key words
ambient air pollutant/child/asthma/outpatient visit/lag effect分类
医药卫生引用本文复制引用
韦丽,龚兴,熊丽林,张艺,孙凤霞,潘伟,许长娣..2019-2023年大气污染物对儿童哮喘的影响[J].环境与职业医学,2025,42(4):408-414,419,8.基金项目
南京市卫生科技发展项目(ZKX20046,YKK21177) （ZKX20046,YKK21177）
