吉首大学学报（自然科学版）2025，Vol.46Issue(2)：78-89,12.DOI:10.13438/j.cnki.jdzk.2025.02.010
基于生物信息学分析MIA3在泛癌中的表达和临床意义
Differential Expression and Clinical Significance of MIA3 Based on Bioinformatics Analysis in Pan-Cancer
摘要
Abstract
To elucidate the expression profile and role of MIA3 in pan-cancer,we collected data from TC-GA and other databases and employed bioinformatics methods to explore the associations between MIA3 and clinical prognosis as well as immune-related characteristics in various cancers.Results showed that MIA3 expression was significantly upregulated in invasive breast cancer,bladder urothelial carcinoma,e-sophageal cancer,head and neck squamous cell carcinoma,renal clear cell carcinoma,mixed renal cancer,hepatocellular carcinoma,lung adenocarcinoma,lung squamous cell carcinoma,prostate cancer,gastric cancer,and gastroesophageal cancer,while it was significantly downregulated in renal chromophobe carci-noma and thyroid carcinoma.The highest mutation frequency of MIA3 was observed in endometrial canc-er(11.4％),followed by gastric cancer(6.1％).In most cancers,especially ovarian serous cystadenoma,brain low-grade glioma,glioblastoma multiforme,renal papillary cell carcinoma,and mixed renal cancer,MIA3 expression was positively correlated with DNA methyltransferase expression.High expression of MIA3 was a risk factor for poor prognosis in adrenocortical carcinoma,renal chromophobe carcinoma,re-nal papillary cell carcinoma,mixed renal cancer,and brain low-grade glioma.Conversely,low expression of MIA3 was associated with poor prognosis in cutaneous melanoma and ovarian serous cystadenoma.The infiltration of cancer immune cells,including B cells,CD4+T lymphocytes,CD8+T lymphocytes,neutrophils,dendritic cells,and macrophages,was significantly correlated with MIA3 expression.Addi-tionally,MIA3 expression was positively correlated with stromal and immune scores in colorectal cancer,mixed renal cancer,head and neck squamous cell carcinoma,renal clear cell carcinoma,testicular germ cell tumors,and renal chromophobe carcinoma.These findings suggest that MIA3 may serve as a valua-ble prognostic biomarker and potential therapeutic target for multiple cancers.However,further studies are needed to confirm these findings.关键词
MIA3/泛癌/生物信息学/免疫细胞/浸润Key words
MIA3/pan-cancer/bioinformatics/immune cell/infiltration分类
动力与电气工程引用本文复制引用
陈功华,欧鹏飞,甄瑶,夏杰,满竞..基于生物信息学分析MIA3在泛癌中的表达和临床意义[J].吉首大学学报（自然科学版）,2025,46(2):78-89,12.基金项目
张家界市科技发展专项项目(2022/09) （2022/09）
