四川精神卫生2025，Vol.38Issue(2)：115-122,8.DOI:10.11886/scjsws20240715001
痛风与阿尔茨海默病的因果关系:一项双样本孟德尔随机化分析
Causal relationship between gout and Alzheimer's disease:a two-sample Mendelian randomization analysis
摘要
Abstract
Background Dementia seriously affects the quality of life and lifespan of elderly people,with Alzheimer's disease(AD)being the most common type of dementia.Previous studies have suggested that gout may reduce the risk of developing AD,but the causal relationship between the two still requires further research.Objective To investigate the potential causal relationship between gout and AD through a two-sample Mendelian randomization(MR)analysis,so as to provide references for the prevention and treatment of AD.Methods Data from Genome-Wide Association Studies(GWAS)extracted in 2024 were analyzed,using pooled data on gout(6 810 cases in the case group and 477 788 cases in the control group)published by UK Biobank in 2021 as the exposure variable,and data on AD(3 899 cases in the case group and 214 893 cases in the control group)published by FinnGen in the same year as the outcome variable.The inverse-variance weighted,MR-Egger regression,weighted median estimation,simple model and weighted model were used to analyze the potential causal relationship between gout and AD.Pleiotropic effects were assessed using MR-Egger regression.Heterogeneity assessment was conducted using Cochran's Q test.The leave-one-out analysis was carried out for sensitivity analysis.And a funnel plot was drawn to detect potential publication bias.Results The inverse-variance weighted analysis demonstrated a negative causal relationship between gout and AD(OR=0.004,95%CI:0～0.700,P<0.05).The plot resembled a symmetrical inversed funnel,indicating the absence of publication bias.No heterogeneity was detected by Cochran's Q test.The MR-Egger regression indicated no significant horizontal pleiotropy.Concerning the reverse directions,no significant associations between AD and gout were noted.Conclusion There is a negative causal relationship between gout and AD,with gout potentially reducing the risk of developing AD.[Funded by The Third Batch of Social Welfare and Basic Research Projects(Medical and Health)of Zhongshan City in 2022(number,2022B3017)]关键词
孟德尔随机化分析/痛风/阿尔茨海默病/因果关系Key words
Mendelian randomization analysis/Gout/Alzheimer's disease/Causality分类
临床医学引用本文复制引用
孔垂嘉,张影,谭振昆,平军娇,张海波,章杰,罗佳丽,刘新霞..痛风与阿尔茨海默病的因果关系:一项双样本孟德尔随机化分析[J].四川精神卫生,2025,38(2):115-122,8.基金项目
2022年度中山市第三批社会公益与基础研究项目(医疗卫生)(项目名称:中山市居民抑郁情绪和认知损害早期筛查及干预措施研究,项目编号:2022B3017) （医疗卫生）
