四川精神卫生2025，Vol.38Issue(2)：123-130,8.DOI:10.11886/scjsws20240723003
精神障碍可能引起高胆固醇血症:一项孟德尔随机化分析
Causal relationship between mental disorders and hypercholesterolemia:a Mendelian randomization analysis
邹茜 1汤妮 1刘欢慧 1张晗婧 1马晓洁1
作者信息
- 1. 川北医学院附属医院,四川 南充 637000
- 折叠
摘要
Abstract
Background Metabolic syndrome(MetS)is highly prevalent in patients with mental disorders,including elevated diastolic or systolic blood pressure,elevated fasting glucose,hypercholesterolemia,abdominal obesity and so on.As an important component of MetS,the relationship between hypercholesterolemia and mental disorder has been extensively reported,whereas few genome-wide association studies(GWAS)have been conducted to identify the causal role of mental disorders in hypercholesterolemia.Objective To explore the potential causal relationship between mental disorders and hypercholesterolemia by two-sample Mendelian randomization(MR)method.Methods Summary data from GWAS were analyzed.Single nucleotide polymorphisms(SNPs)strongly associated with mental disorders were chosen as instrumental variables,and hypercholesterolemia was used as outcome variable.MR analysis utilized inverse-variance weighted(IVW),MR-Egger regression and weighted median estimation(WME)as the primary analytical tool,and supplemented by simple mode(SM)and weighted mode(WM).The causal relationship between mental disorders and the risk of hypercholesterolemia was illustrated in terms of odds ratio(OR).Results A total of 36 SNPs associated with mental disorders were identified as instrumental variables.The primary findings from IVW revealed existence of a causal relationship between mental disorders and hypercholesterolemia(IVW:OR=1.067,95%CI:1.026～1.109,P=0.001).Findings from the additional methods(MR-Egger regression,WME,SM,WM)were basically consistent with those reported in IVW method.Further verification indicated that the causal relationship between mental disorders and the risk of hypercholesterolemia was not affected by genetic polymorphism(P>0.05).The absence of heterogeneity was confirmed through Cochran's Q test and MR-Egger regression(P>0.05).Furthermore,no causal association in the reverse direction was found(P>0.05).Conclusion There is a causal relationship between mental disorders and hypercholesterolemia,and patients with mental disorders may have an increased probability of suffering from hypercholesterolemia.关键词
精神障碍/高胆固醇血症/孟德尔随机化/代谢综合征Key words
Mental disorders/Hypercholesterolemia/Mendelian randomization/Metabolic syndrome分类
临床医学引用本文复制引用
邹茜,汤妮,刘欢慧,张晗婧,马晓洁..精神障碍可能引起高胆固醇血症:一项孟德尔随机化分析[J].四川精神卫生,2025,38(2):123-130,8.
