Abstract
Objective To analyze the association between laboratory parameters and pemphi-gus vulgaris(PV)complicated with infections,aiding in assessment of disease progression and prevention of infection.Methods Clinical data and laboratory test results were collected from 155 PV inpatients,including white blood cell count(WBC),neutrophil count(NEU),lympho-cyte count(LYM),platelet count(PLT),C-reactive protein(CRP),fibrinogen(FIB),albu-min(ALB),globulin(GLB),immunoglobulin E(IgE),immunoglobulin G(IgG),immuno-globulin A(IgA),immunoglobulin M(IgM),complement C3,complement C4,anti-Dsg1 anti-body,and anti-Dsg3 antibody.The differences in these laboratory parameters were compared be-tween PV patients with and without infections.ROC curves were used to compare the diagnostic values of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),C-reactive protein-to-albumin ratio(CAR),and fibrinogen-to-albumin ratio(FAR),and individual parame-ters(including NEU,LYM,PLT,CRP,ALB,FIB)in detecting infections in PV patients.Results Compared with the non-infected group,the infected group exhibited elevated serum lev-els of anti-Dsg1 antibody,anti-Dsg3 antibody,CRP,and FIB,as well as increased PLT counts.Additionally,NLR,PLR,CAR,and FAR were significantly higher,whereas LYM and ALB lev-els were lower in the patients with infections than in those without infections(P＜0.05 for all).ROC curve analysis demonstrated that the NLR,PLR,CAR,and FAR had higher AUC values than the individual parameters.Conclusion The levels of anti-Dsg1 antibody,anti-Dsg3 antibody,NLR,PLR,CAR,and FAR can help identify the infections in PV patients.关键词
寻常型天疱疮/感染/NLR/PLR/CAR/FAR/CD4+T细胞/抗Dsg抗体Key words
pemphigus vulgaris/infection/NLR/PLR/CAR/FAR/CD4+T cells/anti-Dsg antibody
