四川中医2025，Vol.43Issue(4)：203-207,5.
基于GPX4信号通路探讨铁死亡与骨质疏松症的作用机制及中药干预研究
Study on the mechanism offerroptosis and osteoporosis and Chinese medicine intervention based on GPX4signaling pathway
摘要
Abstract
GPX4signaling pathway is one of the major discoveries in bone biology in recent years.It plays an important role in bone metabolism and has become a target for the treatment of osteoporosis.Based on the review of relevant literature,this re-view systematically summarized the mechanism of GPX4pathway regulating ferroptosis and osteoporosis,and discussed the active ingredients of Chinese medicines and Chinese herbal compounds such as Qinghuo pills,Zuogui pills,Bushen Jianpi Huoxue pre-scriptions,etc.to interfere with the process of cell ferroptosis by regulating GPX4pathway,and thus improve the pathological process of osteoporosis.In order to provide reference for the further study of TCM treatment of osteoporosis,but also for the future development of new drugs and clinical practice to provide theoretical support.关键词
GPX4 信号通路/铁死亡/骨质疏松症/中药Key words
GPX4signaling pathway/Ferroptosis/Osteoporosis/Traditional Chinese medicine分类
医药卫生引用本文复制引用
杨青峰,张翔,刘耀忠,刘佳瑞,张凤玲,蒋宜伟..基于GPX4信号通路探讨铁死亡与骨质疏松症的作用机制及中药干预研究[J].四川中医,2025,43(4):203-207,5.基金项目
国家自然科学基金(编号:82160916) （编号:82160916）
2023年内蒙古自治区重点研发和成果转化项目(编号:2023YFSH0049) （编号:2023YFSH0049）
2024年巴彦淖尔市科技计划项目(编号:KL2024061). （编号:KL2024061）
