皮肤性病诊疗学杂志2025，Vol.32Issue(4)：270-279,10.DOI:10.3969/j.issn.1674-8468.2025.04.007
特应性皮炎和感染性胃肠炎的因果关系研究:基于双向孟德尔随机化方法
Causal relationship between atopic dermatitis and infectious gastroenteritis:a bidirectional mendelian randomization study
摘要
Abstract
Objective To investigate the causal relationship between atopic dermatitis(AD)and infectious gastroenteritis using bidirectional two-sample Mendelian randomization(MR),and to assess the risk of infectious gastroenteritis in patients with AD.Methods Based on pooled data from genome-wide association studies,single nucleotide polymorphisms(SNPs),which were in-dependent of each other and strongly associated with both atopic dermatitis(AD)and infectious gastroenteritis,were selected as instrumental variables.MR analysis was performed using inverse variance weighted(IVW),MR Egger's method,weighted median,weighted mode,and simple mode.The Cochran Q test for heterogeneity,the Mendelian randomization pleiotropy residual sum and outlier test,the MR Egger intercept test for multivariate analysis,and the"leave-one-out"method were used for sensitivity analysis.Odds ratio and 95％CI were used as effect indicators to investigate the bidirectional causal relationship between AD and infectious gastroenteritis.Results IVW analysis showed that AD increased the risk of infectious gastroenteritis(OR=1.030,95％CI:1.006～1.056,P=0.015).The results were further confirmed by the weighted median method.However,no evidence suggested that infectious gastroenteritis increased the risk of AD in IVW analysis(OR=1.111,95％CI:0.910～1.357,P=0.299),simple model,weighted model,weighted median and MR Egger analyses.Conclusions This study shows a sig-nificant causal effect of AD on the risk of infectious gastroenteritis,but no evidence supports a re-verse causal relationship.关键词
特应性皮炎/感染性胃肠炎/孟德尔随机化/全基因组关联研究/因果关系Key words
atopic dermatitis/infectious gastroenteritis/mendelian randomization/ge-nome-wide association studies/causality引用本文复制引用
邢可,刘怡,侯楠,张海洋..特应性皮炎和感染性胃肠炎的因果关系研究:基于双向孟德尔随机化方法[J].皮肤性病诊疗学杂志,2025,32(4):270-279,10.基金项目
南阳市科技攻关项目(KJGG079) （KJGG079）
