皮肤性病诊疗学杂志2025，Vol.32Issue(4)：289-296,8.DOI:10.3969/j.issn.1674-8468.2025.04.010
麻风反应的研究进展
Progress in the study of the leprosy reactions
摘要
Abstract
In this article,we systematically reviews the epidemiological characteristics,patho-genesis and risk factors,clinical manifestations,diagnosis and treatment strategies,and predictive biomarkers of leprosy reactions(LR).The integration of epidemiological data indicates that ap-proximately 50％of leprosy patients worldwide still develop LR after multi-drug therapy(MDT).TNFSF15-TNFSF8 locus polymorphisms(such as SNP rs6478108)and TLR9,IL-6 gene variants are significantly associated with the genetic susceptibility to leprosy reactions in type Ⅰ(T1R)and type Ⅱ(T2R),respectively.Studies on immune mechanisms have shown that T1R is driven by the inflammatory cascade mediated by Th1/Th17 cells,while T2R is characterized by immune complex deposition and neutrophil infiltration.Studies further suggest that neutrophil/lymphocyte ratio,expression levels of CD86/CD80/CD40 and anti-PGL-1 can be used as biomarkers for early prediction and diagnosis.Glucocorticoids and thalidomide are the first-line treatments for leprosy reactions,and other drugs(such as methotrexate and TNF-α inhibitor)can be used to improve the prognosis of refractory cases.This review establishes a theoretical framework for the diagnosis and treatment of leprosy reactions(LR)and highlights the need to identify novel biomarkers to predict LR occurrence.Such advances can reduce disability rates and improve patient quality of life,offering valuable guidance for leprosy prevention and control strategies in developing coun-tries.关键词
麻风分枝杆菌/麻风病/Ⅰ型麻风反应/Ⅱ型麻风反应Key words
mycobacterium leprosy/leprosy/type Ⅰ leprosy reaction/type Ⅱ leprosy reaction引用本文复制引用
佘昕妍,林秀球,李阳,林俊杰,王晓华,敖贤..麻风反应的研究进展[J].皮肤性病诊疗学杂志,2025,32(4):289-296,8.基金项目
广东省自然科学基金(2018A0303130318) （2018A0303130318）
