上海交通大学学报（医学版）2025，Vol.45Issue(4)：468-475,8.DOI:10.3969/j.issn.1674-8115.2025.04.009
阻塞性睡眠呼吸暂停与脑成像衍生表型的双向孟德尔随机化研究
Bidirectional Mendelian randomization study of the relationship between brain imaging-derived phenotypes and obstructive sleep apnea
摘要
Abstract
Objective·To elucidate the causal relationship between obstructive sleep apnea(OSA)and imaging-derived phenotypes(IDPs)through two-sample Mendelian randomization(MR)studies.Methods·The genetic data related to OSA were obtained from the genome-wide association study(GWAS)(ncase group=50 200,ncontrol group=401 484)in the FinnGen Biobank R11.Twenty-seven single nucleotide polymorphisms(SNPs)were screened out as instrumental variables of OSA.The GWAS of 3 935 IDPs was based on multimodal neuroimaging data from 39 691 individuals of European ancestry in the UK Biobank.Multiple MR methods,primarily utilizing inverse variance weighted(IVW)analysis,were applied,along with assessments for heterogeneity,pleiotropy,and sensitivity.Results·MR analysis indicated that 8 IDPs were associated with OSA.For example,the genetically determined volume of caudal middle frontal gyrus in the right hemisphere was associated with an increased risk of OSA.A one‒standard-deviation increase in volume corresponded to an 11%higher risk of OSA(IVW OR=1.11,95%CI 1.06‒1.17,P<0.001).Genetically determined reduced risk of OSA was associated with a resting-state functional connectivity characteristic(IVW β=-0.10,95%CI-0.19‒-0.01,P=0.025),representing the functional connectivity strength between the bilateral frontal poles and the right frontal-parietal cortex.The heterogeneity test did not find significant heterogeneity among the instrumental variables.The pleiotropy test did not detect any pleiotropy.The sensitivity analysis indicated stable results.Conclusion·Eight IDPs may have a causal relationship with the occurrence of OSA,among which one IDP shows a bidirectional causal relationship,providing potential targets for non-invasive neuromodulation interventions in OSA.关键词
睡眠呼吸暂停/孟德尔随机化/神经影像Key words
sleep apnea/Mendelian randomization(MR)/neuroimaging分类
医药卫生引用本文复制引用
张慧华,干静,侯媌媌,卢娜..阻塞性睡眠呼吸暂停与脑成像衍生表型的双向孟德尔随机化研究[J].上海交通大学学报（医学版）,2025,45(4):468-475,8.基金项目
上海市科学技术委员会科技创新行动计划(22Y11904100). Shanghai Science and Technology Commission Innovation Action Plan(22Y11904100). （22Y11904100）
