药学研究2025，Vol.44Issue(4)：349-353,376,6.DOI:10.13506/j.cnki.jpr.2025.04.007
吸入用伊曲康唑混悬液的体外雾化特性研究
In vitro study on nebulization characteristics of Itraconazole Suspension for Inhalation
摘要
Abstract
Objective To establish an in vitro evaluation method to study the atomization characteristics of Itraconazole Suspension for Inhalation.Methods The delivery rate and total delivery amount of Itraconazole Suspension for Inhalation were measured by respiratory simulator method,and the aerodynamic particle size distribution(APSD)was studied by NGI's new-generation pharmaceutical disk impactor.Results The delivery rate,total delivery amount,and aerodynamic particle size distribution measured by different brands of atomizer were different,while the results of three batches of samples were similar.Conclusion The method established in this paper can effectively characterize the in vitro atomization characteristics of Itraconazole Suspension for Inhalation,and can be used for the formulation process development and quality control of this preparation.关键词
伊曲康唑/吸入制剂/递送速率/递送总量/空气动力学粒径分布Key words
Itraconazole/Inhalation preparation/Delivery rate/Total delivery/Aerodynamic particle size distribution分类
药学引用本文复制引用
金玉婷,堵伟锋,卫星红,石刘玉,丁竞男..吸入用伊曲康唑混悬液的体外雾化特性研究[J].药学研究,2025,44(4):349-353,376,6.基金项目
安徽省药品监督管理局科技创新项目(No.AHYJ-KJ-202211) （No.AHYJ-KJ-202211）
