药学研究2025，Vol.44Issue(4)：371-376,6.DOI:10.13506/j.cnki.jpr.2025.04.011
代谢重编程与抗肿瘤药物耐药的关系
Relationship between metabolic reprogramming and anti-tumor drug resistance
摘要
Abstract
The progression of cancer is closely related to its unique abnormal energy metabolism.To meet the higher demands for materials,energy,and redox power for rapid proliferation,tumor cells undergo metabolic reprogramming of their metabolic pathways,thereby inducing drug resistance.This article aimed to analyze the roles of glucose metabolism,glutamine metabolism,and lipid metabolism in the energy metabolism of tumor cells,explore the relationship between metabolic reprogramming and drug resistance in tumor therapy,and provide a summary and discussion.This holds significant importance for exploring the mechanisms of tumor drug resistance from a molecular perspective,opening up new avenues for tumor treatment and prognosis for patients.关键词
代谢重编程/肿瘤耐药/葡萄糖代谢/谷氨酰胺代谢/脂质代谢Key words
Metabolic reprogramming/Tumor drug resistance/Glucose metabolism/Glutamine metabolism/Lipid me-tabolism分类
药学引用本文复制引用
陈奕文,张雄飞..代谢重编程与抗肿瘤药物耐药的关系[J].药学研究,2025,44(4):371-376,6.基金项目
江苏省"十四五"重点学科(生物学)建设基金项目(No.035091005023) （生物学）
