药学研究2025，Vol.44Issue(4)：377-383,416,8.DOI:10.13506/j.cnki.jpr.2025.04.012
逆转西妥昔单抗耐药的药物及作用机制研究进展
Research progress of drugs and mechanisms of action to reverse Cetuximab resistance
摘要
Abstract
Cetuximab is mainly used in clinical practice for the treatment of gastrointestinal tumors such as colorectal cancer and gastric cancer.However,with the continuous deepening of clinical applications,the issue of resistance to Cetux-imab has become increasingly prominent,greatly limiting its widespread use.Even if patients are effectively treated with Cetuximab,the remission period lasts up to 12～18 months,after which almost all patients develop secondary resistance,leading to treatment failure.Therefore,in-depth exploration of the resistance mechanism of Cetuximab and finding effective reversal drugs are of great significance for clarifying the optimal combination therapy and targeted treatment mode,and im-proving the therapeutic efficacy of tumors such as colorectal cancer.关键词
西妥昔单抗/耐药/逆转耐药/药物作用/分子机制Key words
Cetuximab/Drug resistance/Reversal of drug resistance/Drug action/Molecular mechanism分类
药学引用本文复制引用
孟瑾,张瑞,苏广珠,王潞..逆转西妥昔单抗耐药的药物及作用机制研究进展[J].药学研究,2025,44(4):377-383,416,8.基金项目
山东省自然科学基金面上项目(No.ZR2023MH016) （No.ZR2023MH016）
济南市临床医学科技发展计划项目(No.202134050) （No.202134050）
山东第一医科大学青年科学基金培育资助计划项目(No.202201-136) （No.202201-136）
