摘要
Abstract
Objective:To investigate the therapeutic effect of fiberoptic bronchoscopy sputum aspiration and bronchoalveolar lavage combined with non-invasive ventilation in patients with severe pneumonia(SP)complicated with respiratory failure.Methods:A retrospective analysis was conducted on the data of 80 patients with SP complicated with respiratory failure admitted to Shaanxi Aerospace Hospital from September 2021 to August 2024,and were divided into a control group and a study group according to the different treatment methods,with 40 cases in each group.The control group received non-invasive ventilation treatment,while the study group received combined treatment with bronchoscopy suction and bronchoalveolar lavage on the basis of the control group.Both groups received continuous treatment for 7 days.The treatment efficacy,Clinical Pulmonary Infection score,inflammatory factors,respiratory mechanics indicators,and lung function were compare between the two groups.Results:The total treatment effective rate of the study group was 95.00%,which was higher than 80.00%of the control group,the difference was statistically significant(P<0.05).After 7 days of treatment,the Clinical Pulmonary Infection Score,tumor necrosis factor-α,high-sensitivity C-reactive protein,Interleukin-6,airway resistance,peak airway pressure of the study group were(4.43±0.65)points,(22.27±3.13)ng/L,(21.43±2.22)mg/L,(45.45±4.12)pg/mL,(8.42±1.11)[cmH2O/(L·s)],(16.15±1.25)cmH2O,respectively,which were lower than(5.80±0.94)points,(27.55±3.24)ng/L,(25.32±3.64)mg/L,(52.26±4.85)pg/mL,(9.86±1.15)[cmH2O/(L·s)],(18.26±1.35)cmH2O of the control group,the difference were statistically significant(P<0.05).After 7 days of treatment,the lung compliance,forced vital capacity,forced expiratory volume in one second and FEV1/FVC of the study group were(71.45±5.27)mL/cmH2O,(3.22±0.51)L,(2.46±0.44)L and(75.56±6.27)%,which were higher than(62.39±5.16)mL/cmH2O,(2.76±0.46)L,(1.95±0.33)L and(67.56±6.13)%of the control group,the difference were statistically significant(P<0.05).Conclusion:The combination of bronchoscopy sputum aspiration and bronchoalveolar lavage with non-invasive ventilation can enhance the therapeutic effect of SP combined with respiratory failure,reduce the degree of pulmonary infection,and improve respiratory mechanics indicators and promote the recovery of lung function.关键词
重症肺炎/呼吸衰竭/纤支镜吸痰及肺泡灌洗/无创通气/呼吸力学指标Key words
Severe pneumonia/Respiratory failure/Bronchoscopy suction and bronchoalveolar lavage/Non-invasive ventilation/Respiratory mechanics indicators分类
临床医学
