世界科学技术-中医药现代化2025，Vol.27Issue(3)：739-751,13.DOI:10.11842/wst.20240524002
长期情志不畅肝失疏泄影响社区中老年人群前瞻记忆的行为学和事件相关电位研究
A Behavior and Event-Related Potentials Study on the of the Effects of Long-Term Emotional Disturbance and Liver Failing to Govern Conveyance and Dispersion on Prospective Memory in Middle-Aged and Elderly People in the Community
摘要
Abstract
Objective To explore the neuroelectrophysiological mechanism of the decline of overall cognitive function and prospective memory,the syndrome manifestation of liver failing to govern conveyance and dispersion of the middle-aged and elderly people in the community with long-term emotional disturbance were evaluated.Methods Eysenck personality questionnaire(EPQ)and general condition questionnaire were used to screen the middle-aged and elderly people from 46 to 65 years old in the community who met the high and low neuroticism criteria,which were included in the long-term emotional disturbance group and the control group.According to the principle of matching sex,age(±2 years)and years of education(±2 years),60 subjects in each group were included.The scores of livers meridian syndrome,anxiety factor,depression factor and the total scores of three factors in the two groups were detected with the emotion rating scale for Ganzangxiang of traditional Chinese medicine.The overall cognitive function,the overall level of prospective memory and the dual-task paradigm of event-related memory were evaluated and event-related potential components were detected.Results Compared to the control group,the total scores of emotion rating scale for Ganzangxiang of traditional Chinese medicine and the scores of liver meridian syndrome factor,anxiety factor and depression factor all increased in the long-term emotional disturbance group significantly(P<0.05).The total scores of MoCA scale(after correction)and the level scores of visual space and executive function,attention and delayed recall decreased significantly(P<0.05),and the total scores of prospective memory questionnaire decreased significantly(P<0.05).The correct rates of ongoing tasks and prospective memory tasks in the event-based prospective memory dual task paradigm were decreased,and the reaction time was prolonged in the long-term emotional disorder group significantly(P<0.05).The amplitude of P200 of ongoing task and prospective memory task were increased in the long-term emotional disorder group(0.05<P<0.10).The latencies of prospective memory task N300 and PP were prolonged significantly(P<0.05).Conclusion The middle-aged and elderly people aged 46-65 years old with long-term emotional disturbance have obvious syndrome symptoms of liver failing to govern conveyance and dispersion,and a significant decline in the overall level of cognitive function and prospective memory occurred.The possible mechanisms mentioned above are that more attention processing resources are consumed in the ongoing task and prospective intention formation stage.The speed of detection and recognition of prospective target clues is slower,and the speed of prospective intention extraction and intention execution is slower.关键词
长期情志不畅/肝失疏泄/痴呆/事件性前瞻记忆/事件相关电位Key words
Long-term emotional disturbance/Liver failing to govern conveyance and dispersion/Dementia/Event-based prospective memory/Event-related potentials分类
医药卫生引用本文复制引用
秦中朋,詹向红,刘永,侯俊林,李宁,赵紫薇,赵凰宏,霍磊,张妍..长期情志不畅肝失疏泄影响社区中老年人群前瞻记忆的行为学和事件相关电位研究[J].世界科学技术-中医药现代化,2025,27(3):739-751,13.基金项目
国家自然科学基金委员会面上项目(81873208):肝失疏泄对正常人群和MCI患者认知功能衰退进程的影响及机制研究,负责人:詹向红 （81873208）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-02):负性情绪积累对aMCI患者执行功能的影响及疏肝法干预机制,负责人:詹向红 （HSRP-DFCTCM-2023-1-02）
河南省自然科学基金委员会面上项目(242300420106):基于"脑-肠轴"理论探讨逍遥散调节AD海马炎症微环境改善空间工作记忆的作用机制,负责人:霍磊. （242300420106）
