世界科学技术-中医药现代化2025，Vol.27Issue(3)：752-761,10.DOI:10.11842/wst.20240310004
从认知灵活性探讨长期负性情绪积累肝失疏泄致遗忘型轻度认知功能障碍的研究进展
Research Progress of Amnesia Mild Cognitive lmpairment Caused by Long-term Negative Emotional Accumulation and Liver Failing to Govern Conveyance and Dispersion from the Perspective of Cognitive Flexibility
摘要
Abstract
Rapid brain aging has become a social and medical problem to be solved urgently,among which amnesia mild cognitive impairment(aMCI)has attracted much attention because it is more likely to develop into Alzheimer's disease(AD)dementia.Many studies at home and abroad have reported that executive function decline is the initiating factor,key damage and sensitive index of cognitive aging,and long-term negative emotional accumulation and liver failing to govern conveyance and dispersion is an important risk factor for aMCI.Soothing liver-qi stagnation therapy can improve the overall cognitive function of aMCI patients,but the above mechanisms need to be further studied and explained.This paper focuses on the cognitive flexibility level of early sensitive components of cognitive decline and one of the core components of executive function,and summarizes the pathogenesis,risk factors,sensitive indicators,event-related potentials and eye tracking techniques of aMCI,and focuses on the effects and research progress of long-term negative emotional accumulation and liver failing to govern conveyance and dispersion on aMCI and cognitive flexibility.The purpose of this study is to provide reference and reference for the intervention and treatment of emotional pathogenesis in patients with aMCI,and to provide new perspectives,methods and ideas for the prevention and treatment of diseases with excessive cognitive decline in traditional Chinese medicine.关键词
长期负性情绪积累/肝失疏泄/遗忘型轻度认知功能障碍/认知灵活性/疏肝法Key words
Long-term negative emotional accumulation/Liver failing to govern conveyance and dispersion/Amnesia mild cognitive impairment(aMCI)/Cognitive flexibility/Soothing liver-qi stagnation therapy分类
医药卫生引用本文复制引用
秦中朋,詹向红,霍磊..从认知灵活性探讨长期负性情绪积累肝失疏泄致遗忘型轻度认知功能障碍的研究进展[J].世界科学技术-中医药现代化,2025,27(3):752-761,10.基金项目
国家自然科学基金委员会面上项目(81873208):肝失疏泄对正常人群和MCI患者认知功能衰退进程的影响及机制研究,负责人:詹向红 （81873208）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-02):负性情绪积累对aMCI患者执行功能的影响及疏肝法干预机制,负责人:詹向红 （HSRP-DFCTCM-2023-1-02）
河南省自然科学基金委员会面上项目(242300420106):基于"脑-肠轴"理论探讨逍遥散调节AD海马炎症微环境改善空间工作记忆的作用机制,负责人:霍磊. （242300420106）
