世界科学技术-中医药现代化2025，Vol.27Issue(3)：762-769,8.DOI:10.11842/wst.20240424006
基于"肠道菌群-线粒体-脂质代谢"失衡探讨"从脾论治"神经退行性疾病
Exploring the Treatment of Neurodegenerative Diseases From the Spleen:Based on The lmbalance of"lntestinal Flora-Mitochondria-Lipid Metabolism"
摘要
Abstract
Neurodegenerative diseases are chronic and progressive diseases of the nervous system.Modern studies have shown that intestinal flora disorders,mitochondrial dysfunction and lipid metabolism abnormalities are closely related to the occurrence and development of neurodegenerative diseases,but the treatment methods are limited.Traditional Chinese medicine believes that spleen is the"the foundation of nurture"and the"the source of Qi and blood biochemistry",Qi deficiency leads to insufficient Qi,blood and body fluid metaplasia,brain dysplasia,leading to the occurrence of neurodegenerative diseases.This paper discusses the mechanism of treating neurodegenerative diseases by spleen from the perspective of"intestinal flora,mitochondria and lipids",and concludes that intestinal flora balance is the material basis of spleen function,mitochondrial homeostasis is an important mechanism of the function of"spleen governing transportation and transformation",and abnormal lipid metabolism is an important manifestation of spleen deficiency and phlegm stasis.Intestinal flora,mitochondria and lipid metabolism may be the potential biological basis for the treatment of neurodegenerative diseases by spleen in traditional Chinese medicine.In order to provide ideas for the clinical research and treatment of neurodegenerative diseases.关键词
神经退行性疾病/从脾论治/肠道菌群/脂质代谢/线粒体Key words
Neurodegenerative diseases/Treatment from spleen/Intestinal flora/Lipid metabolism/Mitochondria分类
医药卫生引用本文复制引用
马驰远,贺晨菲,王新志,刘向哲..基于"肠道菌群-线粒体-脂质代谢"失衡探讨"从脾论治"神经退行性疾病[J].世界科学技术-中医药现代化,2025,27(3):762-769,8.基金项目
河南省卫生健康委员会河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才项目(豫卫中医函[2021]8号),负责人:刘向哲 （仲景工程）
河南省科学技术厅科技攻关项目(242102311277):基于PI3K/Akt/HIF-1α信号通路探讨健脾补肾活血方治疗缺血性中风药效组分及作用机制,负责人:刘向哲 （242102311277）
河南省卫生健康委员会河南省中医药科学研究专项课题(2023ZXZX1077):中风病痰热腑实证诊断标准的建立,负责人:刘向哲. （2023ZXZX1077）
