实验动物与比较医学2025，Vol.45Issue(2)：197-205,9.DOI:10.12300/j.issn.1674-5817.2024.088
浅谈非人灵长类实验动物从业人员的职业健康管理措施
Occupational Health Risk Management Measures for Personnel Handling Non-Human Primate Laboratory Animals:An Overview
摘要
Abstract
Owing to their high genetic and physiological similarities to humans,non-human primates(NHPs)have become pivotal animal models in life sciences research and biomedical development.NHP laboratory animals are not only an ideal platform for exploring the mechanisms of neurological diseases and infectious diseases,but they are also widely used in preclinical safety evaluations of macromolecular drugs,which are considered the"gold standard".Nevertheless,this biological similarity increases the risk of zoonotic disease transmission to personnel working with NHP laboratory animals,their tissues,and body fluids.In light of recent domestic and international outbreaks of zoonotic diseases as well as the implementation of the Biosafety Law,this study examines the occupational risk factors encountered by personnel working with NHPs.This includes biological,chemical,and physical factors.This paper also covers common zoonoses,classification of the corresponding pathogens,transmission routes,risk severity levels,and protocols for post-exposure management.A multidimensional prevention and control framework is proposed,which includes the following components.(1)Risk Assessment and Emergency Response:Regularly identify hazards through an Occupational Health and Safety Committee(OHSC)and develop post-exposure emergency protocols.(2)Optimization of Management Systems:Improve facility design,optimize the allocation of personal protective equipment,and enhance health surveillance and vaccination programs.(3)Technical Training and Standardized Operations:Provide specialized training in NHP laboratory animal ethology and biosafety practices.Additionally,implement intelligent monitoring technologies to reduce the occurrence of aggressive incidents.This paper outlines measures designed to enhance health and safety awareness among personnel working with NHP laboratory animals.It emphasizes the need for strengthened guidance on the use of personal protective equipment(PPE)and the standardization of professional operational practices.The goal is to safeguard personnel health and safety,reduce occupational exposure rates,and effectively prevent occupational diseases related to laboratory animals.关键词
非人灵长类动物/职业健康/职业暴露/生物安全/人兽共患病Key words
Non-human primates/Occupational health/Occupational exposure/Biosafety/Zoonosis分类
医药卫生引用本文复制引用
李倩,陈佳琦,李丽红,张飞燕,毛华明,吕龙宝..浅谈非人灵长类实验动物从业人员的职业健康管理措施[J].实验动物与比较医学,2025,45(2):197-205,9.基金项目
国家重点研发计划项目"灵长类实验动物育种、繁育、SPF猴培育及资源保护研究"(2022YFF0710900)、"灵长类实验动物生物样本资源建设"(2022YFF0710902) （2022YFF0710900）
云南(昆明)院士专家工作站计划项目"贺争鸣实验动物专家工作站"(YSZJGZZ-2022063) （昆明）
云南省贺争鸣专家工作站(202305AF150160) （202305AF150160）
