时珍国医国药2025，Vol.36Issue(8)：1455-1458,4.DOI:10.70976/j.1008-0805.SZGYGY-2025-0809
不同产地当归对小鼠肾功能及组织形态影响的比较研究
Comparative study on the effects of Angelicae Sinensis Radix from different origins on renal function and histomorphology in mice
摘要
Abstract
Objective To compare the effects of Angelicae Sinensis Radix(ASR)from different origins on renal function and histomor-phology in mice.Methods Normal experimental mice were continuously administered with ASR from different regions[1.875 g/(kg·d),containing 0.1 g/mL raw herb]for 22 days.Blood urea nitrogen(BUN)in serum,serum creatinine(Scr),lactate dehydrogenase(LDH)levels,superoxide dismutase(SOD)activity in renal tissue cells,and renal tissue morphology were measured.Results ASR from all regions reduced BUN and Scr contents in serum,decreased LDH activity(P<0.05),and increased SOD activity in renal tissue cells(P<0.05),with no abnormal changes in renal morphology.ASR of Linxia showed stronger effects in reducing BUN,and ASR from Min County and Weiyuan County had a stronger effect in lowering SCR.ASR from Linxia and Li County exhibited greater reduction in serum LDH,and that of Weiyuan significantly enhanced renal SOD activity.No histomorphological abnormalities of ASR from different origins were observed in any group.Conclusion Prolonged administration(22 consecutive days)of ASR from Min County,Weiyuan County,Linxia,Li County and Yunnan regions can improve the antioxidant capacity of experimental mice,reduce oxidative products,and demonstrate protective effects on the renal tissues without causing damage.关键词
当归/产地差异/肾功能/组织形态/抗氧化Key words
Angelicae Sinensis Radix(当归)/Regional variation/Renal function/Tissue morphology/Antioxidant分类
医药卫生引用本文复制引用
任鹏飞,邓毅,杨秀娟..不同产地当归对小鼠肾功能及组织形态影响的比较研究[J].时珍国医国药,2025,36(8):1455-1458,4.基金项目
国家自然科学基金地区基金(81960723) （81960723）
甘肃省高等学校创新基金项目(2021B-157) （2021B-157）
西北中藏药协同创新中心开放基金(Xbzzy-2022-08) （Xbzzy-2022-08）
河南省2019年民办普通高校品牌专业建设点项目(2019-527) （2019-527）
