现代妇产科进展2025，Vol.34Issue(4)：255-263,9.DOI:10.13283/j.cnki.xdfckjz.2025.04.030
基于整合素家族基因构建及验证子宫内膜癌的预后模型
Construction and validation of prognostic model based on integrin family genes for endo-metrial cancer
摘要
Abstract
Objective:To identify and analyze the integrin family genes associated with the prognosis of endometrial cancer(EC),and subsequently develop a prognostic model based on the optimal combination of these genes.Methods:The transcriptome and clinical data of EC patients were acquired from TCGA database.The limma package was used to identify differenti-ally expressed genes,and the survminer package was employed for identifying prognostic genes.The LASSO algorithm provided by the glmnet package was utilized to construct a prognostic model based on genes from the integrin family.The prognostic model was evaluated for its pre-dictive efficacy through Kaplan-Meier and ROC curves.The independence analysis was conduc-ted using multivariate Cox regression analysis.The enrichment analysis was conducted using the DOSE,ClusterProfiler,GSVA,and GSEA packages.The TIDE algorithm was employed for the prediction of immunotherapy response.The oncoPredict package was utilized for drug response prediction.Results:The prognostic model for EC was established based on the optimal combina-tion of integrin family genes including ITGA7,ITGAL,ITGA6,ITGB1BP2,and ITGA10.The prognostic model revealed a significantly worse prognosis for EC patients in the high-risk group compared to those in the low-risk group.The prognostic model demonstrated excellent predictive efficacy and served as an independent prognostic factor for EC.The patients with high-and low-risk demonstrated distinct enrichments in pathways.The patients with low-risk demonstrated a higher likelihood of benefiting from immunotherapy as well as the administration of cisplatin,cytarabine,docetaxel,paclitaxel,tamoxifen,and vinorelbine.Conclusion:The prognostic model utilizing integrin family genes serves as a valuable tool for predicting the prognosis of EC pa-tients,thereby facilitating personalized treatment strategies.关键词
子宫内膜癌/整合素/预后模型/生物信息学Key words
Endometrial carcinoma/Integrin/Prognostic model/Bioinformatics分类
临床医学引用本文复制引用
姜瑞娜,郑剑锋,林雪芬,汪思萍,孙阳..基于整合素家族基因构建及验证子宫内膜癌的预后模型[J].现代妇产科进展,2025,34(4):255-263,9.基金项目
福建省妇科恶性肿瘤精准治疗临床医学研究中心(No:2022Y2015) （No:2022Y2015）
