生物加工过程2025，Vol.23Issue(2)：182-189,8.DOI:10.3969/j.issn.1672-3678.2025.02.008
砷剂暴露后体内残留以及健康风险评估的研究进展
Research progress on risk assessment of human health upon arsenic exposure
摘要
Abstract
Arsenic(As),a naturally existing element in the environmental media,is often utilized and exposed in occupational and non-occupational settings.In the past 30 years,some arsenic agents have been successfully developed for the treatment of malignant tumors,especially acute promyelocytic leukemia.Nevertheless,long-term exposure to arsenic can cause potential hazards.Herein,we reviewed the long-term follow-up studies on environmental and drug-induced arsenic exposure,and summarized the resultant potential problems,including skin disorders,alterations in the digestive/nervous/respiratory/endocrine/vascular/genital systems,damage of offspring health,and the onset of malignancies.Therefore,it is particularly important to strengthen monitoring and develop individual treatment plan in the process of arsenic exposure.In addition,the supplementation of trace elements and the intake of antioxidants may play a beneficial role in alleviating chronic arsenic poisoning.关键词
砷/环境暴露/化疗/长期随访/慢性并发症Key words
arsenic/environmental exposure/chemotherapy/long-term follow-up/chronic complications分类
药学引用本文复制引用
缪晓帆,杨涛,李思洋..砷剂暴露后体内残留以及健康风险评估的研究进展[J].生物加工过程,2025,23(2):182-189,8.基金项目
国家重点研发计划(2022YFC3502302) （2022YFC3502302）
国家自然科学基金面上项目(82174276) （82174276）
